PDB entry 6gxa

View 6gxa on RCSB PDB site
Description: crystal structure of schistosoma mansoni hdac8 complexed with an hydroxamate 2
Deposited on 2018-06-27, released 2018-08-15
The last revision was dated 2018-08-29, with a file datestamp of 2018-08-24.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5H660 (Start-440)
      • expression tag (441-446)
  • Chain 'C':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5H660 (Start-440)
      • expression tag (441-446)
  • Chain 'D':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
  • Heterogens: TB8, ZN, K, DMF, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6gxaA (A:)
    hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
    tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
    aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
    vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
    grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
    fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
    evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
    dlnkliydydqvyqlynltgmgslvpr
    

    Sequence, based on observed residues (ATOM records):
    >6gxaA (A:)
    svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
    fhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgslaa
    asalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvssqtrvlyvdldlhhg
    dgveeafwysprvvtfsvhhaspgffpgtgtwnmlpiflngagrgrfsafnlpleegind
    ldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfyplsgylyaikkils
    wkvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeld
    idyfpdsiqkhhrrileqlrnyadlnkliydydqvyqly
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6gxaB (B:)
    hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
    tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
    aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
    vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
    grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
    fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
    evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
    dlnkliydydqvyqlynltgmgslvpr
    

    Sequence, based on observed residues (ATOM records):
    >6gxaB (B:)
    svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
    fhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgslaa
    asalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstqtrvlyvdldlhh
    gdgveeafwysprvvtfsvhhaspgffpgtgtwnmlpiflngagrgrfsafnlpleegin
    dldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfypslsgylyaikki
    lswkvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfe
    ldidyfphetldsiqkhhrrileqlrnyadlnkliydydqvyqlynltgmgslvpr
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6gxaC (C:)
    hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
    tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
    aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
    vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
    grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
    fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
    evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
    dlnkliydydqvyqlynltgmgslvpr
    

    Sequence, based on observed residues (ATOM records):
    >6gxaC (C:)
    svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
    fhsteyvdalkklqmlhcekeltaddellmdsfslnydcpgfpsvfdyslaavqgslaaa
    salicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstqtrvlyvdldlhhg
    dgveeafwysprvvtfsvhhaspgffpgtgtwnmlpiflngagrgrfsafnlpleegind
    ldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfypslsgylyaikkil
    swkvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfel
    didyfphdsiqkhhrrileqlrnyadlnkliydydqvyqlynltgmgslvpr
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6gxaD (D:)
    hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
    tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
    aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
    vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
    grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
    fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
    evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
    dlnkliydydqvyqlynltgmgslvpr
    

    Sequence, based on observed residues (ATOM records):
    >6gxaD (D:)
    svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
    fhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgslaa
    asalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvssqtrvlyvdldlhhg
    dgveeafwysprvvtfsvhhaspgffpgtgtwnlpiflngagrgrfsafnlpleegindl
    dwsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfypslsgylyaikkils
    wkvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeld
    idyfpdsiqkhhrrileqlrnyadlnkliydydqvyqly