PDB entry 6gx3

View 6gx3 on RCSB PDB site
Description: crystal structure of schistosoma mansoni hdac8 complexed with an hydroxamate 1
Deposited on 2018-06-26, released 2018-08-15
The last revision was dated 2018-08-29, with a file datestamp of 2018-08-24.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5H660 (Start-440)
      • expression tag (441-446)
  • Chain 'C':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5H660 (Start-440)
      • expression tag (441-446)
  • Chain 'D':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
  • Heterogens: FF2, ZN, K, GOL, DMF, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6gx3A (A:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6gx3A (A:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceeeltaddellmdsfslnydcpgfpsvfdyslaavqgslaaa
salicrhcevvinwgggwhhakrseasgfcylndivlaihrlvssqtrvlyvdldlhhgd
gveeafwysprvvtfsvhhaspgffpgtgtwnlpiflngagrgrfsafnlpleegindld
wsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfyplsgylyaikkilswk
vptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeldid
yfpdsiqkhhrrileqlrnyadlnkliydydqvyqly

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6gx3B (B:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6gx3B (B:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceltaddellmdsfslnydcpgfpsvfdyslaavqgslaaasa
licrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstqtrvlyvdldlhhgdg
veeafwysprvvtfsvhhaspgffpgtgtwniflngagrgrfsafnlpleegindldwsn
aigpildslniviqpsyvvvqcgadclatdphrifrltnfypslsgylyaikkilswkvp
tlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeldidyf
phedsiqkhhrrileqlrnyadlnkliydydqvyqlynltgmgslvpr

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6gx3C (C:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6gx3C (C:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceeltaddellmdsfslnydcpgfpsvfdyslaavqgslaaas
alicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstqtrvlyvdldlhhgd
gveeafwysprvvtfsvhhaspgffpgtgtwniflngagrgrfsafnlpleegindldws
naigpildslniviqpsyvvvqcgadclatdphrifrltnfyplsgylyaikkilswkvp
tlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeldidyf
phldsiqkhhrrileqlrnyadlnkliydydqvyqlynltgmgslvpr

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6gx3D (D:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6gx3D (D:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceeeltaddellmdsfslnydcpgfpsvfdyslaavqgslaaa
salicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstqtrvlyvdldlhhg
dgveeafwysprvvtfsvhhaspgffpgtgtwnlpiflngagrgrfsafnlpleegindl
dwsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfypslsgylyaikkils
wkvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeld
idyfpdsiqkhhrrileqlrnyadlnkliydydqvyqly