PDB entry 6gwp

View 6gwp on RCSB PDB site
Description: Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64)
Class: hydrolase
Keywords: plasminogen activator inhibitor-1, PAI-1, PAI-1-stab, serpin, protease inhibitor, serine protease inhibitor, nanobody, antibody fragment, protein complex, hydrolase
Deposited on 2018-06-25, released 2020-01-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-11, with a file datestamp of 2020-03-06.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: plasminogen activator inhibitor-1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05121 (Start-378)
      • engineered mutation (149)
      • engineered mutation (153)
      • engineered mutation (300)
      • engineered mutation (318)
      • engineered mutation (353)
    Domains in SCOPe 2.08: d6gwpa_
  • Chain 'B':
    Compound: VHH-2g-42
    Species: VICUGNA PACOS [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 6GWP (0-End)
    Domains in SCOPe 2.08: d6gwpb_
  • Chain 'C':
    Compound: VHH-2w-64
    Species: VICUGNA PACOS [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 6GWP (0-120)
    Domains in SCOPe 2.08: d6gwpc_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6gwpA (A:)
vhhppsyvahlasdfgvrvfqqvaqaskdrnvvfspygvasvlamlqlttggetqqqiqa
amgfkiddkgmapalrhlykelmgpwnkdeisttdaifvqrdlklvqgfmphffrlfrst
vkqvdfseverarfiindwvkthtkgmishllgtgavdqltrlvlvnalyfngqwktpfp
dssthrrlfhksdgstvsvpmmaqtnkfnytefttpdghyydilelpyhgdtlsmfiaap
yekevplsaltnilsaqlishwkgnmtrlprllvlpkfsletevdlrkplenlgmtdmfr
pfqadftslsdqeplhvalalqkvkievnesgtvassstavivsarmapeeiiidrpflf
vvrhnptgtvlfmgqvmep

    Sequence, based on observed residues (ATOM records): (download) 
    >6gwpA (A:)
syvahlasdfgvrvfqqvaqaskdrnvvfspygvasvlamlqlttggetqqqiqaamgfk
iddkgmapalrhlykelmgpwnkdeisttdaifvqrdlklvqgfmphffrlfrstvkqvd
fseverarfiindwvkthtkgmishllgtgavdqltrlvlvnalyfngqwktpfpdssth
rrlfhksdgstvsvpmmaqtnkfnytefttpdghyydilelpyhgdtlsmfiaapyekev
plsaltnilsaqlishwkgnmtrlprllvlpkfsletevdlrkplenlgmtdmfrpfqad
ftslsdqeplhvalalqkvkievnesgtavivsarmapeeiiidrpflfvvrhnptgtvl
fmgqvmep

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6gwpB (B:)
qvqlvesggglvqpggrlrlscaasgftfrtyamqwyrqspgterelvaaisniggvtdy
gdsvkgrftisrdnakttvylemnslkpedtatyycsavrlpqrywgrgtqvtvss

    Sequence, based on observed residues (ATOM records): (download) 
    >6gwpB (B:)
qvqlvesggglvqpggrlrlscaasgftfrtyamqwyrqspgterelvaaisniggvtdy
gdsvkgrftisrdnakttvylemnslkpedtatyycsavrlpqrywgrgtqvtvs

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6gwpC (C:)
qvqlvesggglvqaggslrlscaasgftfddysiawfrqapgkeregvscisssdgsayy
adsvkgrftissdnakntvylqmnslkpedtavyycaavwarvcrnpydywgqgtqvtvs
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