PDB entry 6gw3

View 6gw3 on RCSB PDB site
Description: Structure of TKS from Cannabis sativa in complex with CoA
Class: ligase
Keywords: 3, 5, 7-trioxododecanoyl-CoA synthase, polyketide synthase, PKS type III, LIGASE
Deposited on 2018-06-21, released 2019-10-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-10-09, with a file datestamp of 2019-10-04.
Experiment type: XRAY
Resolution: 1.39 Å
R-factor: N/A
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3,5,7-trioxododecanoyl-CoA synthase
    Species: Cannabis sativa [TaxId:3483]
    Gene: OLS, CAN24, PKS-1, TKS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6gw3a1, d6gw3a2
  • Chain 'B':
    Compound: 3,5,7-trioxododecanoyl-CoA synthase
    Species: Cannabis sativa [TaxId:3483]
    Gene: OLS, CAN24, PKS-1, TKS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6gw3b1, d6gw3b2
  • Chain 'C':
    Compound: 3,5,7-trioxododecanoyl-CoA synthase
    Species: Cannabis sativa [TaxId:3483]
    Gene: OLS, CAN24, PKS-1, TKS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6gw3c1, d6gw3c2
  • Chain 'D':
    Compound: 3,5,7-trioxododecanoyl-CoA synthase,3,5,7-trioxododecanoyl-CoA synthase
    Species: Cannabis sativa [TaxId:3483]
    Gene: OLS, CAN24, PKS-1, TKS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6gw3d1, d6gw3d2
  • Heterogens: COA, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6gw3A (A:)
gamanhlraegpasvlaigtanpenillqdefpdyyfrvtksehmtqlkekfrkicdksm
irkrncflneehlkqnprlvehemqtldarqdmlvvevpklgkdacakaikewgqpkski
thliftsasttdmpgadyhcakllglspsvkrvmmyqlgcygggtvlriakdiaennkga
rvlavccdimaclfrgpsesdlellvgqaifgdgaaavivgaepdesvgerpifelvstg
qtilpnsegtigghireaglifdlhkdvpmlisnniekclieaftpigisdwnsifwith
pggkaildkveeklhlksdkfvdsrhvlsehgnmssstvlfvmdelrkrsleegksttgd
gfewgvlfgfgpgltvervvvrsvpiky

    Sequence, based on observed residues (ATOM records): (download) 
    >6gw3A (A:)
hlraegpasvlaigtanpenillqdefpdyyfrvtksehmtqlkekfrkicdksmirkrn
cflneehlkqnprlvehemqtldarqdmlvvevpklgkdacakaikewgqpkskithlif
tsasttdmpgadyhcakllglspsvkrvmmyqlgcygggtvlriakdiaennkgarvlav
ccdimaclfrgpsesdlellvgqaifgdgaaavivgaepdesvgerpifelvstgqtilp
nsegtigghireaglifdlhkdvpmlisnniekclieaftpigisdwnsifwithpggka
ildkveeklhlksdkfvdsrhvlsehgnmssstvlfvmdelrkrsleegksttgdgfewg
vlfgfgpgltvervvvrsvpiky

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6gw3B (B:)
gamanhlraegpasvlaigtanpenillqdefpdyyfrvtksehmtqlkekfrkicdksm
irkrncflneehlkqnprlvehemqtldarqdmlvvevpklgkdacakaikewgqpkski
thliftsasttdmpgadyhcakllglspsvkrvmmyqlgcygggtvlriakdiaennkga
rvlavccdimaclfrgpsesdlellvgqaifgdgaaavivgaepdesvgerpifelvstg
qtilpnsegtigghireaglifdlhkdvpmlisnniekclieaftpigisdwnsifwith
pggkaildkveeklhlksdkfvdsrhvlsehgnmssstvlfvmdelrkrsleegksttgd
gfewgvlfgfgpgltvervvvrsvpiky

    Sequence, based on observed residues (ATOM records): (download) 
    >6gw3B (B:)
hlraegpasvlaigtanpenillqdefpdyyfrvtksehmtqlkekfrkicdksmirkrn
cflneehlkqnprlvehemqtldarqdmlvvevpklgkdacakaikewgqpkskithlif
tsasttdmpgadyhcakllglspsvkrvmmyqlgcygggtvlriakdiaennkgarvlav
ccdimaclfrgpsesdlellvgqaifgdgaaavivgaepdesvgerpifelvstgqtilp
nsegtigghireaglifdlhkdvpmlisnniekclieaftpigisdwnsifwithpggka
ildkveeklhlksdkfvdsrhvlsehgnmssstvlfvmdelrkrsleegksttgdgfewg
vlfgfgpgltvervvvrsvpiky

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6gw3C (C:)
gamanhlraegpasvlaigtanpenillqdefpdyyfrvtksehmtqlkekfrkicdksm
irkrncflneehlkqnprlvehemqtldarqdmlvvevpklgkdacakaikewgqpkski
thliftsasttdmpgadyhcakllglspsvkrvmmyqlgcygggtvlriakdiaennkga
rvlavccdimaclfrgpsesdlellvgqaifgdgaaavivgaepdesvgerpifelvstg
qtilpnsegtigghireaglifdlhkdvpmlisnniekclieaftpigisdwnsifwith
pggkaildkveeklhlksdkfvdsrhvlsehgnmssstvlfvmdelrkrsleegksttgd
gfewgvlfgfgpgltvervvvrsvpiky

    Sequence, based on observed residues (ATOM records): (download) 
    >6gw3C (C:)
lraegpasvlaigtanpenillqdefpdyyfrvtksehmtqlkekfrkicdksmirkrnc
flneehlkqnprlvehemqtldarqdmlvvevpklgkdacakaikewgqpkskithlift
sasttdmpgadyhcakllglspsvkrvmmyqlgcygggtvlriakdiaennkgarvlavc
cdimaclfrgpsesdlellvgqaifgdgaaavivgaepdesvgerpifelvstgqtilpn
segtigghireaglifdlhkdvpmlisnniekclieaftpigisdwnsifwithpggkai
ldkveeklhlksdkfvdsrhvlsehgnmssstvlfvmdelrkrsleegksttgdgfewgv
lfgfgpgltvervvvrsvpiky

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6gw3D (D:)
gamanhlraegpasvlaigtanpenillqdefpdyyfrvtksehmtqlkekfrkicdksm
irkrncflneehlkqnprlvehemqtldarqdmlvvevpklgamanhlraegpasvlaig
tanpenillqdefpdyyfrvtksehmtqlkekfrkicdksmirkrncflneehlkqnprl
vehemqtldarqdmlvvevpklgkdacakaikewgqpkskithliftsasttdmpgadyh
cakllglspsvkrvmmyqlgcygggtvlriakdiaennkgarvlavccdimaclfrgpse
sdlellvgqaifgdgaaavivgaepdesvgerpifelvstgqtilpnsegtigghireag
lifdlhkdvpmlisnniekclieaftpigisdwnsifwithpggkaildkveeklhlksd
kfvdsrhvlsehgnmssstvlfvmdelrkrsleegksttgdgfewgvlfgfgpgltverv
vvrsvpiky

    Sequence, based on observed residues (ATOM records): (download) 
    >6gw3D (D:)
lraegpasvlaigtanpenillqdefpdyyfrvtksehmtqlkekfrkicdksmirkrnc
flneehlkqnprlvehemqtldarqdmlvvevpklgkdacakaikewgqpkskithlift
sasttdmpgadyhcakllglspsvkrvmmyqlgcygggtvlriakdiaennkgarvlavc
cdimaclfrgpsesdlellvgqaifgdgaaavivgaepdesvgerpifelvstgqtilpn
segtigghireaglifdlhkdvpmlisnniekclieaftpigisdwnsifwithpggkai
ldkveeklhlksdkfvdsrhvlsehgnmssstvlfvmdelrkrsleegksttgdgfewgv
lfgfgpgltvervvvrsvpi