PDB entry 6gvw

View 6gvw on RCSB PDB site
Description: crystal structure of the brca1-a complex
Deposited on 2018-06-21, released 2019-07-10
The last revision was dated 2019-08-21, with a file datestamp of 2019-08-16.
Experiment type: XRAY
Resolution: 3.75 Å
R-factor: N/A
AEROSPACI score: 0.07 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: BRCA1-A complex subunit Abraxas 1
    Species: Mus musculus [TaxId:10090]
    Gene: Abraxas1, Abra1, Ccdc98, Fam175a
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Lys-63-specific deubiquitinase BRCC36
    Species: Mus musculus [TaxId:10090]
    Gene: Brcc3, Brcc36, C6.1a
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: BRISC and BRCA1-A complex member 2
    Species: Mus musculus [TaxId:10090]
    Gene: Babam2, Bre
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: BRISC and BRCA1-A complex member 1
    Species: Mus musculus [TaxId:10090]
    Gene: Babam1, Merit40, Nba1
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: BRCA1-A complex subunit RAP80
    Species: Mus musculus [TaxId:10090]
    Gene: Uimc1, Rap80, Rip110, Rxrip110
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5U5Q9 (4-End)
      • expression tag (1-3)
  • Chain 'F':
    Compound: BRCA1-A complex subunit Abraxas 1
    Species: Mus musculus [TaxId:10090]
    Gene: Abraxas1, Abra1, Ccdc98, Fam175a
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Lys-63-specific deubiquitinase BRCC36
    Species: Mus musculus [TaxId:10090]
    Gene: Brcc3, Brcc36, C6.1a
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: BRISC and BRCA1-A complex member 2
    Species: Mus musculus [TaxId:10090]
    Gene: Babam2, Bre
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: BRISC and BRCA1-A complex member 1
    Species: Mus musculus [TaxId:10090]
    Gene: Babam1, Merit40, Nba1
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: BRCA1-A complex subunit RAP80
    Species: Mus musculus [TaxId:10090]
    Gene: Uimc1, Rap80, Rip110, Rxrip110
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5U5Q9 (4-End)
      • expression tag (1-3)
  • Heterogens: ZN, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6gvwA (A:)
gggrmegestlgvlsgfvlgaltfhhlntdsdtegfllgemkgeaknsitdsqmdnvkvv
ytidiqkyipcyrlfsfynslgevnehalkkvlsnvrktvvgwykfrrhsdqimtfreql
lhrnlqthlsspelvfllltpsittescsthclehalykpqrglfhrvplvvtnlgmsdq
lgyktepasctstvfsravrthssqffnedgslkevhkinemyaavqeelksicqkveqs
erevekllmdvnqlkevrrtqqaratgageknvqrnpqenillcqalrtffpesevlhsc
vislknrhispsgcnvnhhvdvvdqltlmveyvyspeaspvptaqlrkrkaldthdqgsv
krprlletesrpsvaasrsrhqdkassssldidiemgspeddadyprsptf

    Sequence, based on observed residues (ATOM records):
    >6gvwA (A:)
gestlgvlsgfvlgaltfhhlntdsdtegfllgemkgeaknsitdsqmdnvkvvytidiq
kyipcyrlfsfynslgevnehalkkvlsnvrktvvgwykfrrhsdqimtfreqllhrnlq
thlsspelvfllltpsittescsthclehalykpqrglfhrvplvvtnlgmsdqlgykte
pasctstvfsravrthssqffnedgslkevhkinemyaavqeelksicqkveqserevek
llmdvnqlkevrrtqqaratpqenillcqalrtffpesevlhscvislknrhispsgcnv
nhhvdvvdqltl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6gvwB (B:)
gggrmavqvvqavqavhlesdaflvclnhalstekeevmglcigelnddirsdskftytg
temrtvqekmdtirivhihsviilrrsdkrkdrveispeqlsaasteaerlaeltgrpmr
vvgwyhshphitvwpshvdvrtqamyqmmdqgfvglifscfiedkntktgrvlytcfqsi
qaqksseyerieipihivphitigkvclesavelpkilcqeeqdayrrihslthldsvtk
ihngsvftknlcsqmsavsgpllqwledrleqnqqhlqelqqekeelmeelssle

    Sequence, based on observed residues (ATOM records):
    >6gvwB (B:)
avqavhlesdaflvclnhalstekeevmglcigelnddiirivhihsviilrrsdkrkdr
veispeqlsaasteaerlaeltgrpmrvvgwyhshphitvwpshvdvrtqamyqmmdqgf
vglifscfiedkntktgrvlytcfqsiqaqksseyerieipihivphitigkvclesave
lpkilcqeeqdayrrihslthldsvtkihngsvftknlcsqmsavsgpllqwledrleqn
qqhlqelqqekeelmeelssle

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6gvwC (C:)
gggrmspeialnrispmlspfissvvrngkvgldatnclritdlksgctsltpgpncdrf
klhipyagetlkwdiifnaqypelppdfifgedaeflpdpsalhnlaswnpsnpeclllv
vkelvqqyhqfqcgrlressrlmfeyqtlleepqygenmeiyagkknnwtgefsarfllk
lpvdfsniptyllkdvnedpgedvallsvsfedteatqvypklylspriehalggssalh
ipafpgggclidyvpqvchlltnkvqyviqgyhkrreyiaaflshfgtgvveydaegftk
ltlllmwkdfcflvhidlplffprdqptltfqsvyhftnsgqlysqaqknypysprwdgn
emakrakayfktfvpqfqeaafangkl

    Sequence, based on observed residues (ATOM records):
    >6gvwC (C:)
mspeialnrispmlspfissvvrngkvgldatnclritdlksgctsltpgpncdrfklhi
pyagetlkwdiifnaqypelppdfifgedaeflpdpsalhnlaswnpsnpeclllvvkel
vqqyhqfqcgrlressrlmfeyqtlleepqygenmeiyagkknnwtgefsarfllklpvd
fsniptyllkdvnedpgedvallsvsfedteatqvypklylspriehalggssalhipaf
pgggclidyvpqvchlltnkvqyviqgyhkrreyiaaflshfgtgvveydaegftkltll
lmwkdfcflvhidlplffprdqptltfqsvyhftnsgqlysqaqknypysprwdgnemak
rakayfktfvpqfqeaafangkl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6gvwD (D:)
gggrmevaeanspteeeeeeeeegeetiseprphtrsnpegaedralgaqasvgsrsege
geaatadggaasvpgagpkpwqvpasasevqirtprvncpekviicldlseemsvpkles
fngsrtnalnvsqkmvemfvrtkhkidkshefalvvvnddsawlsgltsdprelcsclyd
letascstfnleglfsliqqktelpvtenvqtipppyvvrtilvysrppcqpqfsltepm
kkmfqcpyfffdivyihngteekeedmswkdmfafmgsldtkgasykyevalagpalelh
ncmakllahplqrpcqthasyslleedeeageeeatv

    Sequence, based on observed residues (ATOM records):
    >6gvwD (D:)
asevqirtprvncpekviicldlseemsvpklesfngsrtnalnvsqkmvemfvrtkhki
dkshefalvvvnddsawlsgltsdprelcsclydletascstfnleglfsliqqktelpv
tenvqtipppyvvrtilvysrppcqpqfsltepmkkmfqcpyfffdivyihngteekeed
mswkdmfafmgsldtkgasykyevalagpalelhncmakllahplqrpcqthasyslle

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6gvwE (E:)
gggrhyywgipfcpagvdpnqytnvilcqlevyqkslkmaqrqlvkkrgfgepvlprppf
liqn

    Sequence, based on observed residues (ATOM records):
    >6gvwE (E:)
ggrhyywgipfcpagvdpnqytnvilcqlevyqkslkmaqrqlvkkrgfgepvlprppf

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6gvwF (F:)
gggrmegestlgvlsgfvlgaltfhhlntdsdtegfllgemkgeaknsitdsqmdnvkvv
ytidiqkyipcyrlfsfynslgevnehalkkvlsnvrktvvgwykfrrhsdqimtfreql
lhrnlqthlsspelvfllltpsittescsthclehalykpqrglfhrvplvvtnlgmsdq
lgyktepasctstvfsravrthssqffnedgslkevhkinemyaavqeelksicqkveqs
erevekllmdvnqlkevrrtqqaratgageknvqrnpqenillcqalrtffpesevlhsc
vislknrhispsgcnvnhhvdvvdqltlmveyvyspeaspvptaqlrkrkaldthdqgsv
krprlletesrpsvaasrsrhqdkassssldidiemgspeddadyprsptf

    Sequence, based on observed residues (ATOM records):
    >6gvwF (F:)
megestlgvlsgfvlgaltfhhlntdsdtegfllgemkgeaknsitdsqmdnvkvvytid
iqkyipcyrlfsfynslgevnehalkkvlsnvrktvvgwykfrrhsdqimtfreqllhrn
lqthlsspelvfllltpsittescsthclehalykpqrglfhrvplvvtnlgmsdqlgyk
tepasctstvfsravrthssqffnedgslkevhkinemyaavqeelksicqkveqserev
ekllmdvnqlkevrrtqqaratgqenillcqalrtffpesevlhscvislknrhispsgc
nvnhhvdvvdqltlmveyvy

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6gvwG (G:)
gggrmavqvvqavqavhlesdaflvclnhalstekeevmglcigelnddirsdskftytg
temrtvqekmdtirivhihsviilrrsdkrkdrveispeqlsaasteaerlaeltgrpmr
vvgwyhshphitvwpshvdvrtqamyqmmdqgfvglifscfiedkntktgrvlytcfqsi
qaqksseyerieipihivphitigkvclesavelpkilcqeeqdayrrihslthldsvtk
ihngsvftknlcsqmsavsgpllqwledrleqnqqhlqelqqekeelmeelssle

    Sequence, based on observed residues (ATOM records):
    >6gvwG (G:)
avqavhlesdaflvclnhalstekeevmglcigelnddiirivhihsviilrrsdkrkdr
veispeqlsaasteaerlaeltgrpmrvvgwyhshphitvwpshvdvrtqamyqmmdqgf
vglifscfiedkntktgrvlytcfqsiqaqksseyerieipihivphitigkvclesave
lpkilcqeeqdayrrihslthldsvtkihngsvftknlcsqmsavsgpllqwledrleqn
qqhlqelqqekeelmeelssle

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6gvwH (H:)
gggrmspeialnrispmlspfissvvrngkvgldatnclritdlksgctsltpgpncdrf
klhipyagetlkwdiifnaqypelppdfifgedaeflpdpsalhnlaswnpsnpeclllv
vkelvqqyhqfqcgrlressrlmfeyqtlleepqygenmeiyagkknnwtgefsarfllk
lpvdfsniptyllkdvnedpgedvallsvsfedteatqvypklylspriehalggssalh
ipafpgggclidyvpqvchlltnkvqyviqgyhkrreyiaaflshfgtgvveydaegftk
ltlllmwkdfcflvhidlplffprdqptltfqsvyhftnsgqlysqaqknypysprwdgn
emakrakayfktfvpqfqeaafangkl

    Sequence, based on observed residues (ATOM records):
    >6gvwH (H:)
mspeialnrispmlspfissvvrngkvgldatnclritdlksgctsltpgpncdrfklhi
pyagetlkwdiifnaqypelppdfifgedaeflpdpsalhnlaswnpsnpeclllvvkel
vqqyhqfqcgrlressrlmfeyqtlleepqygenmeiyagkknnwtgefsarfllklpvd
fsniptyllkdvnedpgedvallsvsfedteatqvypklylspriehalggssalhipaf
pgggclidyvpqvchlltnkvqyviqgyhkrreyiaaflshfgtgvveydaegftkltll
lmwkdfcflvhidlplffprdqptltfqsvyhftnsgqlysqaqknypysprwdgnemak
rakayfktfvpqfqeaafangkl

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6gvwI (I:)
gggrmevaeanspteeeeeeeeegeetiseprphtrsnpegaedralgaqasvgsrsege
geaatadggaasvpgagpkpwqvpasasevqirtprvncpekviicldlseemsvpkles
fngsrtnalnvsqkmvemfvrtkhkidkshefalvvvnddsawlsgltsdprelcsclyd
letascstfnleglfsliqqktelpvtenvqtipppyvvrtilvysrppcqpqfsltepm
kkmfqcpyfffdivyihngteekeedmswkdmfafmgsldtkgasykyevalagpalelh
ncmakllahplqrpcqthasyslleedeeageeeatv

    Sequence, based on observed residues (ATOM records):
    >6gvwI (I:)
sevqirtprvncpekviicldlseemsvpklesfngsrtnalnvsqkmvemfvrtkhkid
kshefalvvvnddsawlsgltsdprelcsclydletascstfnleglfsliqqktelpvt
envqtipppyvvrtilvysrppcqpqfsltepmkkmfqcpyfffdivyihngteekeedm
swkdmfafmgsldtkgasykyevalagpalelhncmakllahplqrpcqthasyslle

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6gvwJ (J:)
gggrhyywgipfcpagvdpnqytnvilcqlevyqkslkmaqrqlvkkrgfgepvlprppf
liqn

    Sequence, based on observed residues (ATOM records):
    >6gvwJ (J:)
ggrhyywgipfcpagvdpnqytnvilcqlevyqkslkmaqrqlvkkrgfgepvlprppf