PDB entry 6gvh

View 6gvh on RCSB PDB site
Description: crystal structure of pi3k alpha in complex with 3-(2-amino- benzooxazol-5-yl)-4-chloro-1-isopropyl-1h-pyrazolo[3,4-d]pyrimidin-6- ylamine
Deposited on 2018-06-21, released 2019-10-02
The last revision was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 2.74 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CA
    Database cross-references and differences (RAF-indexed):
  • Heterogens: FDH, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6gvhA (A:)
nreekilnreigfaigmpvcefdmvkdpevqdfrrnilnvckeavdlrdlnsphsramyv
yppnvesspelpkhiynkldkgqiivviwvivspnndkqkytlkinhdcvpeqviaeair
kktrsmllsseqlklcvleyqgkyilkvcgcdeyflekyplsqykyirscimlgrmpnlm
lmakeslysqlpmdcftmpsysrristatpymngetstkslwvinsalrikilcatyvnv
nirdidkiyvrtgiyhggeplcdnvntqrvpcsnprwnewlnydiyipdlpraarlclsi
csvkgrkgakeehcplawgninlfdytdtlvsgkmalnlwpvphgledllnpigvtgsnp
nketpclelefdwfssvvkfpdmsvieehanwsvsreagfsyshaglsnrlardnelren
dkeqlkaistrdplseiteqekdflwshrhycvtipeilpklllsvkwnsrdevaqmycl
vkdwppikpeqamelldcnypdpmvrgfavrclekyltddklsqyliqlvqvlkyeqyld
nllvrfllkkaltnqrighfffwhlksemhnktvsqrfglllesycracgmylkhlnrqv
eameklinltdilkqekkdetqkvqmkflveqmrrpdfmdalqgflsplnpahqlgnlrl
eecrimssakrplwlnwenpdimsellfqnneiifkngddlrqdmltlqiirimeniwqn
qgldlrmlpygclsigdcvglievvrnshtimqiqckgglkgalqfnshtlhqwlkdknk
geiydaaidlftrscagycvatfilgigdrhnsnimvkddgqlfhidfghfldhkkkkfg
ykrervpfvltqdfliviskgaqectktreferfqemcykaylairqhanlfinlfsmml
gsgmpelqsfddiayirktlaldkteqealeyfmkqmndahhggwttkmdwifhtikqha
ln

    Sequence, based on observed residues (ATOM records):
    >6gvhA (A:)
nreekilnreigfaigmpvcefdmvkdpevqdfrrnilnvckeavdlrdlnsphsramyv
yppnvesspelpkhiynkldkgqiivviwvivspnndkqkytlkinhdcvpeqviaeair
kktrsmllsseqlklcvleyqgkyilkvcgcdeyflekyplsqykyirscimlgrmpnlm
lmakeslysqlpmdcftmpsysrrtstkslwvinsalrikilcatyvnvnirdidkiyvr
tgiyhggeplcdnvntqrvpcsnprwnewlnydiyipdlpraarlclsicsvkkeehcpl
awgninlfdytdtlvsgkmalnlwpvphgledllnpigvtgsnpnketpclelefdwfss
vvkfpdmsvieehanwsvsreagfsyshaglsnrlardnelrendkeqlkaistrdplse
iteqekdflwshrhycvtipeilpklllsvkwnsrdevaqmyclvkdwppikpeqamell
dcnypdpmvrgfavrclekyltddklsqyliqlvqvlkyeqyldnllvrfllkkaltnqr
ighfffwhlksemhnktvsqrfglllesycracgmylkhlnrqveameklinltdilkqe
kkdetqkvqmkflveqmrrpdfmdalqgflsplnpahqlgnlrleecrimssakrplwln
wenpdimsellfqnneiifkngddlrqdmltlqiirimeniwqnqgldlrmlpygclsig
dcvglievvrnshtimqiqcnshtlhqwlkdknkgeiydaaidlftrscagycvatfilg
igdrhnsnimvkddgqlfhidfghfldhkkrervpfvltqdfliviskgaqectktrefe
rfqemcykaylairqhanlfinlfsmmlgsgmpelqsfddiayirktlaldkteqealey
fmkqmndahhggw