PDB entry 6gvc

View 6gvc on RCSB PDB site
Description: Structure of ArhGAP12 bound to G-Actin
Class: hydrolase
Keywords: GAP, RAC, Actin, HYDROLASE
Deposited on 2018-06-20, released 2019-03-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-23, with a file datestamp of 2019-10-18.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Actin, alpha skeletal muscle
    Species: Oryctolagus cuniculus [TaxId:9986]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gvca1, d6gvca2
  • Chain 'B':
    Compound: Actin, alpha skeletal muscle
    Species: Oryctolagus cuniculus [TaxId:9986]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gvcb1, d6gvcb2
  • Chain 'C':
    Compound: Actin, alpha skeletal muscle
    Species: Oryctolagus cuniculus [TaxId:9986]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gvcc1, d6gvcc2
  • Chain 'D':
    Compound: Actin, alpha skeletal muscle
    Species: Oryctolagus cuniculus [TaxId:9986]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gvcd1, d6gvcd2
  • Chain 'Q':
    Compound: Rho GTPase-activating protein 12
    Species: Mus musculus [TaxId:10090]
    Gene: Arhgap12
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8C0D4 (7-End)
      • expression tag (0-6)
  • Chain 'R':
    Compound: Rho GTPase-activating protein 12
    Species: Mus musculus [TaxId:10090]
    Gene: Arhgap12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gvcr_
  • Chain 'S':
    Compound: Rho GTPase-activating protein 12
    Species: Mus musculus [TaxId:10090]
    Gene: Arhgap12
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8C0D4 (7-End)
      • expression tag (6)
  • Chain 'T':
    Compound: Rho GTPase-activating protein 12
    Species: Mus musculus [TaxId:10090]
    Gene: Arhgap12
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8C0D4 (7-End)
      • expression tag (0-6)
  • Heterogens: EDO, LAB, ATP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6gvcA (A:)
mcdedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdea
qskrgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrek
mtqimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrl
dlagrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataasssslek
syelpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannv
msggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwit
kqeydeagpsivhrkcf

    Sequence, based on observed residues (ATOM records): (download) 
    >6gvcA (A:)
ttalvcdngsglvkagfagddapravfpsivgrprkdsyvgdeaqstlkypiehgiitnw
ddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimfetfnvpamyvaiqav
lslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrdltdylmkiltergys
fvttaereivrdikeklcyvaldfenemataassssleksyelpdgqvitignerfrcpe
tlfqpsfigmesagihettynsimkcdidirkdlyannvmsggttmypgiadrmqkeita
lapstmkikiiapperkysvwiggsilaslstfqqmwitkqeydeagpsivhrkcf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6gvcB (B:)
mcdedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdea
qskrgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrek
mtqimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrl
dlagrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataasssslek
syelpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannv
msggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwit
kqeydeagpsivhrkcf

    Sequence, based on observed residues (ATOM records): (download) 
    >6gvcB (B:)
ttalvcdngsglvkagfagddapravfpsivgrprsyvgdeaqskrgiltlkypiehgii
tnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimfetfnvpamyvai
qavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrdltdylmkilter
gysfvttaereivrdikeklcyvaldfenemataassssleksyelpdgqvitignerfr
cpetlfqpsfigmesagihettynsimkcdidirkdlyannvmsggttmypgiadrmqke
italapstmkikiiapperkysvwiggsilaslstfqqmwitkqeydeagpsivhrkcf

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6gvcC (C:)
mcdedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdea
qskrgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrek
mtqimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrl
dlagrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataasssslek
syelpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannv
msggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwit
kqeydeagpsivhrkcf

    Sequence, based on observed residues (ATOM records): (download) 
    >6gvcC (C:)
ttalvcdngsglvkagfagddapravfpsivgrprsyvgdeaqskrgiltlkypiehgii
tnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimfetfnvpamyvai
qavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrdltdylmkilter
gysfvttaereivrdikeklcyvaldfenemataassssleksyelpdgqvitignerfr
cpetlfqpsfigmesagihettynsimkcdidirkdlyannvmsggttmypgiadrmqke
italapstmkikiiapperkysvwiggsilaslstfqqmwitkqeydeagpsivhrkcf

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6gvcD (D:)
mcdedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdea
qskrgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrek
mtqimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrl
dlagrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataasssslek
syelpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannv
msggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwit
kqeydeagpsivhrkcf

    Sequence, based on observed residues (ATOM records): (download) 
    >6gvcD (D:)
talvcdngsglvkagfagddapravfpsivgrprdsyvgdeaqsiltlkypiehgiitnw
ddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimfetfnvpamyvaiqav
lslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrdltdylmkiltergys
fvttaereivrdikeklcyvaldfenemataassssleksyelpdgqvitignerfrcpe
tlfqpsfigmesagihettynsimkcdidirkdlyannvmsggttmypgiadrmqkeita
lapstmkikiiapperkysvwiggsilaslstfqqmwitkqeydeagpsivhrkcf

  • Chain 'Q':
    No sequence available.

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >6gvcR (R:)
pgipgstqkktkknlkkfltrrptlqavrekgyikdqvfgsnlanlcqrengtvpkfvkl
ciehveehgldvdgiyrvsgnlaviqklrfavnhdekldlndskwedihvitgalkmffr
elpeplftfnhfndfvnaikqeprqrvtavkdlirqlpkpnqdtmqilfrhlkrvienge
knrmtyqsiaivfgptllkperetgniavhtvyqnqivelillelstvfgr

    Sequence, based on observed residues (ATOM records): (download) 
    >6gvcR (R:)
qkktkknlkkfltrrptlqavrekgyikdqvfgsnlanlcqrengtvpkfvklciehvee
hgldvdgiyrvsgnlaviqklrfavnhdekldlndskwedihvitgalkmffrelpeplf
tfnhfndfvnaikqeprqrvtavkdlirqlpkpnqdtmqilfrhlkrviengeknrmtyq
siaivfgptllkperhtvyqnqivelillelstvfg

  • Chain 'S':
    No sequence available.

  • Chain 'T':
    No sequence available.