PDB entry 6gvc

View 6gvc on RCSB PDB site
Description: Structure of ArhGAP12 bound to G-Actin
Class: hydrolase
Keywords: GAP, RAC, Actin, HYDROLASE
Deposited on 2018-06-20, released 2019-03-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-03-27, with a file datestamp of 2019-03-22.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Actin, alpha skeletal muscle
    Species: Oryctolagus cuniculus [TaxId:9986]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6gvca1, d6gvca2
  • Chain 'B':
    Compound: Actin, alpha skeletal muscle
    Species: Oryctolagus cuniculus [TaxId:9986]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6gvcb1, d6gvcb2
  • Chain 'C':
    Compound: Actin, alpha skeletal muscle
    Species: Oryctolagus cuniculus [TaxId:9986]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6gvcc1, d6gvcc2
  • Chain 'D':
    Compound: Actin, alpha skeletal muscle
    Species: Oryctolagus cuniculus [TaxId:9986]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6gvcd1, d6gvcd2
  • Chain 'Q':
    Compound: Rho GTPase-activating protein 12
    Species: Mus musculus [TaxId:10090]
    Gene: Arhgap12
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8C0D4 (7-End)
      • expression tag (0-6)
  • Chain 'R':
    Compound: Rho GTPase-activating protein 12
    Species: Mus musculus [TaxId:10090]
    Gene: Arhgap12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6gvcr_
  • Chain 'S':
    Compound: Rho GTPase-activating protein 12
    Species: Mus musculus [TaxId:10090]
    Gene: Arhgap12
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8C0D4 (7-End)
      • expression tag (6)
  • Chain 'T':
    Compound: Rho GTPase-activating protein 12
    Species: Mus musculus [TaxId:10090]
    Gene: Arhgap12
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8C0D4 (7-End)
      • expression tag (0-6)
  • Heterogens: EDO, LAB, ATP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6gvcA (A:)
    mcdedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdea
    qskrgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrek
    mtqimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrl
    dlagrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataasssslek
    syelpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannv
    msggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwit
    kqeydeagpsivhrkcf
    

    Sequence, based on observed residues (ATOM records): (download)
    >6gvcA (A:)
    ttalvcdngsglvkagfagddapravfpsivgrprkdsyvgdeaqstlkypiehgiitnw
    ddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimfetfnvpamyvaiqav
    lslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrdltdylmkiltergys
    fvttaereivrdikeklcyvaldfenemataassssleksyelpdgqvitignerfrcpe
    tlfqpsfigmesagihettynsimkcdidirkdlyannvmsggttmypgiadrmqkeita
    lapstmkikiiapperkysvwiggsilaslstfqqmwitkqeydeagpsivhrkcf
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6gvcB (B:)
    mcdedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdea
    qskrgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrek
    mtqimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrl
    dlagrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataasssslek
    syelpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannv
    msggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwit
    kqeydeagpsivhrkcf
    

    Sequence, based on observed residues (ATOM records): (download)
    >6gvcB (B:)
    ttalvcdngsglvkagfagddapravfpsivgrprsyvgdeaqskrgiltlkypiehgii
    tnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimfetfnvpamyvai
    qavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrdltdylmkilter
    gysfvttaereivrdikeklcyvaldfenemataassssleksyelpdgqvitignerfr
    cpetlfqpsfigmesagihettynsimkcdidirkdlyannvmsggttmypgiadrmqke
    italapstmkikiiapperkysvwiggsilaslstfqqmwitkqeydeagpsivhrkcf
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6gvcC (C:)
    mcdedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdea
    qskrgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrek
    mtqimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrl
    dlagrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataasssslek
    syelpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannv
    msggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwit
    kqeydeagpsivhrkcf
    

    Sequence, based on observed residues (ATOM records): (download)
    >6gvcC (C:)
    ttalvcdngsglvkagfagddapravfpsivgrprsyvgdeaqskrgiltlkypiehgii
    tnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimfetfnvpamyvai
    qavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrdltdylmkilter
    gysfvttaereivrdikeklcyvaldfenemataassssleksyelpdgqvitignerfr
    cpetlfqpsfigmesagihettynsimkcdidirkdlyannvmsggttmypgiadrmqke
    italapstmkikiiapperkysvwiggsilaslstfqqmwitkqeydeagpsivhrkcf
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >6gvcD (D:)
    mcdedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdea
    qskrgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrek
    mtqimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrl
    dlagrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataasssslek
    syelpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannv
    msggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwit
    kqeydeagpsivhrkcf
    

    Sequence, based on observed residues (ATOM records): (download)
    >6gvcD (D:)
    talvcdngsglvkagfagddapravfpsivgrprdsyvgdeaqsiltlkypiehgiitnw
    ddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimfetfnvpamyvaiqav
    lslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrdltdylmkiltergys
    fvttaereivrdikeklcyvaldfenemataassssleksyelpdgqvitignerfrcpe
    tlfqpsfigmesagihettynsimkcdidirkdlyannvmsggttmypgiadrmqkeita
    lapstmkikiiapperkysvwiggsilaslstfqqmwitkqeydeagpsivhrkcf
    

  • Chain 'Q':
    No sequence available.

  • Chain 'R':
    Sequence, based on SEQRES records: (download)
    >6gvcR (R:)
    pgipgstqkktkknlkkfltrrptlqavrekgyikdqvfgsnlanlcqrengtvpkfvkl
    ciehveehgldvdgiyrvsgnlaviqklrfavnhdekldlndskwedihvitgalkmffr
    elpeplftfnhfndfvnaikqeprqrvtavkdlirqlpkpnqdtmqilfrhlkrvienge
    knrmtyqsiaivfgptllkperetgniavhtvyqnqivelillelstvfgr
    

    Sequence, based on observed residues (ATOM records): (download)
    >6gvcR (R:)
    qkktkknlkkfltrrptlqavrekgyikdqvfgsnlanlcqrengtvpkfvklciehvee
    hgldvdgiyrvsgnlaviqklrfavnhdekldlndskwedihvitgalkmffrelpeplf
    tfnhfndfvnaikqeprqrvtavkdlirqlpkpnqdtmqilfrhlkrviengeknrmtyq
    siaivfgptllkperhtvyqnqivelillelstvfg
    

  • Chain 'S':
    No sequence available.

  • Chain 'T':
    No sequence available.