PDB entry 6guc

View 6guc on RCSB PDB site
Description: CDK2/CyclinA in complex with SU9516
Class: cell cycle
Keywords: cdk2, cyclina, inhibitor, cell cycle
Deposited on 2018-06-19, released 2018-12-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-01-30, with a file datestamp of 2019-01-25.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2, CDKN2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (4-End)
      • expression tag (3)
    Domains in SCOPe 2.08: d6guca1, d6guca2
  • Chain 'B':
    Compound: Cyclin-A2
    Species: Bos taurus [TaxId:9913]
    Gene: CCNA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gucb1, d6gucb2
  • Chain 'C':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2, CDKN2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (4-End)
      • expression tag (3)
    Domains in SCOPe 2.08: d6gucc1, d6gucc2
  • Chain 'D':
    Compound: Cyclin-A2
    Species: Bos taurus [TaxId:9913]
    Gene: CCNA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gucd1, d6gucd2
  • Heterogens: SU9, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6gucA (A:)
gpgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllk
elnhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqgla
fchshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillg
ckyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdy
kpsfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl
rl

    Sequence, based on observed residues (ATOM records): (download) 
    >6gucA (A:)
smenfqkvekigegtygvvykarnkltgevvalkkitegvpstaireisllkelnhpniv
klldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvl
hrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyystav
diwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwa
rqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6gucB (B:)
gvnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
vlrmehlvlkvlafdlaaptinqfltqyflhqqpanckveslamflgelslidadpylky
lpsviaaaafhlalytvtgqswpeslvqktgytletlkpclldlhqtylrapqhaqqsir
ekyknskyhgvsllnppetlnvhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6gucB (B:)
vnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnet
lhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqv
lrmehlvlkvlafdlaaptinqfltqyflhqqpanckveslamflgelslidadpylkyl
psviaaaafhlalytvtgqswpeslvqktgytletlkpclldlhqtylrapqhaqqsire
kyknskyhgvsllnppetlnv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6gucC (C:)
gpgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllk
elnhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqgla
fchshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillg
ckyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdy
kpsfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl
rl

    Sequence, based on observed residues (ATOM records): (download) 
    >6gucC (C:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6gucD (D:)
gvnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
vlrmehlvlkvlafdlaaptinqfltqyflhqqpanckveslamflgelslidadpylky
lpsviaaaafhlalytvtgqswpeslvqktgytletlkpclldlhqtylrapqhaqqsir
ekyknskyhgvsllnppetlnvhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6gucD (D:)
vnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnet
lhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqv
lrmehlvlkvlafdlaaptinqfltqyflhqqpanckveslamflgelslidadpylkyl
psviaaaafhlalytvtgqswpeslvqktgytletlkpclldlhqtylrapqhaqqsire
kyknskyhgvsllnppetlnv