PDB entry 6gu7

View 6gu7 on RCSB PDB site
Description: CDK1/Cks2 in complex with AZD5438
Class: cell cycle
Keywords: cdk1, cks2, inhibitor, cell cycle
Deposited on 2018-06-19, released 2018-12-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-01-30, with a file datestamp of 2019-01-25.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cyclin-dependent kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK1, CDC2, CDC28A, CDKN1, P34CDC2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gu7a_
  • Chain 'B':
    Compound: Cyclin-dependent kinases regulatory subunit 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CKS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gu7b_
  • Chain 'C':
    Compound: Cyclin-dependent kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK1, CDC2, CDC28A, CDKN1, P34CDC2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gu7c_
  • Chain 'D':
    Compound: Cyclin-dependent kinases regulatory subunit 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CKS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gu7d_
  • Chain 'E':
    Compound: Cyclin-dependent kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK1, CDC2, CDC28A, CDKN1, P34CDC2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gu7e_
  • Chain 'F':
    Compound: Cyclin-dependent kinases regulatory subunit 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CKS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gu7f_
  • Chain 'G':
    Compound: Cyclin-dependent kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK1, CDC2, CDC28A, CDKN1, P34CDC2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gu7g_
  • Chain 'H':
    Compound: Cyclin-dependent kinases regulatory subunit 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CKS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gu7h_
  • Heterogens: FB8, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6gu7A (A:)
gplgsmedytkiekigegtygvvykgrhkttgqvvamkkirleseeegvpstaireisll
kelrhpnivslqdvlmqdsrlylifeflsmdlkkyldsippgqymdsslvksylyqilqg
ivfchsrrvlhrdlkpqnlliddkgtikladfglarafgipirvythevvtlwyrspevl
lgsarystpvdiwsigtifaelatkkplfhgdseidqlfrifralgtpnnevwpeveslq
dykntfpkwkpgslashvknldengldllskmliydpakrisgkmalnhpyfndldnqik
km

    Sequence, based on observed residues (ATOM records): (download) 
    >6gu7A (A:)
medytkiekigegtygvvykgrhkttgqvvamkkirleseeegvpstaireisllkelrh
pnivslqdvlmqdsrlylifeflsmdlkkyldsippgqymdsslvksylyqilqgivfch
srrvlhrdlkpqnlliddkgtikladfglarafgivtlwyrspevllgsarystpvdiws
igtifaelatkkplfhgdseidqlfrifralgtpnnevwpeveslqdykntfpkwkpgsl
ashvknldengldllskmliydpakrisgkmalnhpyfndldnq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6gu7B (B:)
gplgsmahkqiyysdkyfdehyeyrhvmlprelskqvpkthlmseeewrrlgvqqslgwv
hymihepephillfrrplpkdqqk

    Sequence, based on observed residues (ATOM records): (download) 
    >6gu7B (B:)
qiyysdkyfdehyeyrhvmlprelskqvpkthlmseeewrrlgvqqslgwvhymihepep
hillfrrplpk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6gu7C (C:)
gplgsmedytkiekigegtygvvykgrhkttgqvvamkkirleseeegvpstaireisll
kelrhpnivslqdvlmqdsrlylifeflsmdlkkyldsippgqymdsslvksylyqilqg
ivfchsrrvlhrdlkpqnlliddkgtikladfglarafgipirvythevvtlwyrspevl
lgsarystpvdiwsigtifaelatkkplfhgdseidqlfrifralgtpnnevwpeveslq
dykntfpkwkpgslashvknldengldllskmliydpakrisgkmalnhpyfndldnqik
km

    Sequence, based on observed residues (ATOM records): (download) 
    >6gu7C (C:)
medytkiekigegtygvvykgrhkttgqvvamkkirleseeegvpstaireisllkelrh
pnivslqdvlmqdsrlylifeflsmdlkkyldsippgqymdsslvksylyqilqgivfch
srrvlhrdlkpqnlliddkgtikladfglarafgipirvythevvtlwyrspevllgsar
ystpvdiwsigtifaelatkkplfhgdseidqlfrifralgtpnnevwpeveslqdyknt
fpkwkpgslashvknldengldllskmliydpakrisgkmalnhpyfndld

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6gu7D (D:)
gplgsmahkqiyysdkyfdehyeyrhvmlprelskqvpkthlmseeewrrlgvqqslgwv
hymihepephillfrrplpkdqqk

    Sequence, based on observed residues (ATOM records): (download) 
    >6gu7D (D:)
qiyysdkyfdehyeyrhvmlprelskqvpkthlmseeewrrlgvqqslgwvhymihepep
hillfrrplpk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6gu7E (E:)
gplgsmedytkiekigegtygvvykgrhkttgqvvamkkirleseeegvpstaireisll
kelrhpnivslqdvlmqdsrlylifeflsmdlkkyldsippgqymdsslvksylyqilqg
ivfchsrrvlhrdlkpqnlliddkgtikladfglarafgipirvythevvtlwyrspevl
lgsarystpvdiwsigtifaelatkkplfhgdseidqlfrifralgtpnnevwpeveslq
dykntfpkwkpgslashvknldengldllskmliydpakrisgkmalnhpyfndldnqik
km

    Sequence, based on observed residues (ATOM records): (download) 
    >6gu7E (E:)
medytkiekigegtygvvykgrhkttgqvvamkkirleseeegvpstaireisllkelrh
pnivslqdvlmqdsrlylifeflsmdlkkyldsippgqymdsslvksylyqilqgivfch
srrvlhrdlkpqnlliddkgtikladfglarafgipvtlwyrspevllgsarystpvdiw
sigtifaelatkkplfhgdseidqlfrifralgtpnnevwpeveslqdykntfpkwkpgs
lashvknldengldllskmliydpakrisgkmalnhpyfndldn

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6gu7F (F:)
gplgsmahkqiyysdkyfdehyeyrhvmlprelskqvpkthlmseeewrrlgvqqslgwv
hymihepephillfrrplpkdqqk

    Sequence, based on observed residues (ATOM records): (download) 
    >6gu7F (F:)
kqiyysdkyfdehyeyrhvmlprelskqvpkthlmseeewrrlgvqqslgwvhymihepe
phillfrrplp

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6gu7G (G:)
gplgsmedytkiekigegtygvvykgrhkttgqvvamkkirleseeegvpstaireisll
kelrhpnivslqdvlmqdsrlylifeflsmdlkkyldsippgqymdsslvksylyqilqg
ivfchsrrvlhrdlkpqnlliddkgtikladfglarafgipirvythevvtlwyrspevl
lgsarystpvdiwsigtifaelatkkplfhgdseidqlfrifralgtpnnevwpeveslq
dykntfpkwkpgslashvknldengldllskmliydpakrisgkmalnhpyfndldnqik
km

    Sequence, based on observed residues (ATOM records): (download) 
    >6gu7G (G:)
medytkiekigegtygvvykgrhkttgqvvamkkirleseeegvpstaireisllkelrh
pnivslqdvlmqdsrlylifeflsmdlkkyldsippgqymdsslvksylyqilqgivfch
srrvlhrdlkpqnlliddkgtikladfglarafgipvtlwyrspevllgsarystpvdiw
sigtifaelatkkplfhgdseidqlfrifralgtpnnevwpeveslqdykntfpkwkpgs
lashvknldengldllskmliydpakrisgkmalnhpyfndld

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6gu7H (H:)
gplgsmahkqiyysdkyfdehyeyrhvmlprelskqvpkthlmseeewrrlgvqqslgwv
hymihepephillfrrplpkdqqk

    Sequence, based on observed residues (ATOM records): (download) 
    >6gu7H (H:)
kqiyysdkyfdehyeyrhvmlprelskqvpkthlmseeewrrlgvqqslgwvhymihepe
phillfrrplpk