PDB entry 6gt1

View 6gt1 on RCSB PDB site
Description: nek7 bound to purine inhibitor
Deposited on 2018-06-15, released 2018-07-18
Made obsolete by 6s73 on 2020-06-10

The last revision was dated 2020-06-10, with a file datestamp of 2020-06-05.
Experiment type: XRAY
Resolution: 3.5 Å
R-factor: N/A
AEROSPACI score: 0.07 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase nek7
    Species: Homo sapiens [TaxId:9606]
    Gene: NEK7
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8TDX7
      • engineered mutation (85)
      • engineered mutation (96)
      • engineered mutation (179)
  • Chain 'B':
    Compound: serine/threonine-protein kinase nek7
    Species: Homo sapiens [TaxId:9606]
    Gene: NEK7
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8TDX7
      • engineered mutation (85)
      • engineered mutation (96)
      • engineered mutation (179)
  • Chain 'C':
    Compound: serine/threonine-protein kinase nek7
    Species: Homo sapiens [TaxId:9606]
    Gene: NEK7
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8TDX7
      • engineered mutation (85)
      • engineered mutation (96)
      • engineered mutation (179)
  • Chain 'D':
    Compound: serine/threonine-protein kinase nek7
    Species: Homo sapiens [TaxId:9606]
    Gene: NEK7
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8TDX7
      • engineered mutation (85)
      • engineered mutation (96)
  • Heterogens: F9N, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6gt1A (A:)
mdeqsqgmqgppvpqfqpqkalrpdmgyntlanfriekkigrgqfsevyraaclldgvpv
alkkvqifdlmdakaradcikeidlhkqlnhpnvikfyasfiednelnivleladagdls
rmikhfkkqkrlipertvwkyfvqlcsalehmhsrrvmhrdikpanvfitatgvvklgdf
glgrffsskttaahslvgtpyymsperihengynfksdiwslgcllyemaalqspfygdk
mnlyslckkieqcdypplpsdhyseelrqlvnmcinpdpekrpdvtyvydvakrmhacta
ss

    Sequence, based on observed residues (ATOM records):
    >6gt1A (A:)
alrpdmgyntlanfriekkigrgqfsevyraaclldgvpvalkkvqifdlmdakaradci
keidlhkqlnhpnvikfyasfiednelnivleladagdlsrmikhfkkqkrlipertvwk
yfvqlcsalehmhsrrvmhrdikpanvfitatgvvklgdfgllvgtpyymsperihengy
nfksdiwslgcllyemaalqspfygdkmnlyslckkieqcdypplpsdhyseelrqlvnm
cinpdpekrpdvtyvydvakrmhacta

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6gt1B (B:)
mdeqsqgmqgppvpqfqpqkalrpdmgyntlanfriekkigrgqfsevyraaclldgvpv
alkkvqifdlmdakaradcikeidlhkqlnhpnvikfyasfiednelnivleladagdls
rmikhfkkqkrlipertvwkyfvqlcsalehmhsrrvmhrdikpanvfitatgvvklgdf
glgrffsskttaahslvgtpyymsperihengynfksdiwslgcllyemaalqspfygdk
mnlyslckkieqcdypplpsdhyseelrqlvnmcinpdpekrpdvtyvydvakrmhacta
ss

    Sequence, based on observed residues (ATOM records):
    >6gt1B (B:)
kalrpdmgyntlanfriekkigrgqfsevyraaclldgvpvalkkvqifdlmdakaradc
ikeidlhkqlnhpnvikfyasfiednelnivleladagdlsrmikhfkkqkrlipertvw
kyfvqlcsalehmhsrrvmhrdikpanvfitatgvvklgdfglglvgtpyymsperihen
gynfksdiwslgcllyemaalqspfygdkmnlyslckkieqcdypplpsdhyseelrqlv
nmcinpdpekrpdvtyvydvakrmhacta

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6gt1C (C:)
mdeqsqgmqgppvpqfqpqkalrpdmgyntlanfriekkigrgqfsevyraaclldgvpv
alkkvqifdlmdakaradcikeidlhkqlnhpnvikfyasfiednelnivleladagdls
rmikhfkkqkrlipertvwkyfvqlcsalehmhsrrvmhrdikpanvfitatgvvklgdf
glgrffsskttaahslvgtpyymsperihengynfksdiwslgcllyemaalqspfygdk
mnlyslckkieqcdypplpsdhyseelrqlvnmcinpdpekrpdvtyvydvakrmhacta
ss

    Sequence, based on observed residues (ATOM records):
    >6gt1C (C:)
gyntlanfriekkigrgqfsevyraaclldgvpvalkkvqifdlmdakaradcikeidlh
kqlnhpnvikfyasfiednelnivleladagdlsrmikhfkkqkrlipertvwkyfvqlc
salehmhsrrvmhrdikpanvfitatgvvklgdfgtpyymsperihengynfksdiwslg
cllyemaalqspfygdkmnlyslckkieqcdypplpsdhyseelrqlvnmcinpdpekrp
dvtyvydvakrmhacta

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6gt1D (D:)
mdeqsqgmqgppvpqfqpqkalrpdmgyntlanfriekkigrgqfsevyraaclldgvpv
alkkvqifdlmdakaradcikeidlhkqlnhpnvikfyasfiednelnivleladagdls
rmikhfkkqkrlipertvwkyfvqlcsalehmhsrrvmhrdikpanvfitatgvvklgdf
glgrffsskttaahslvgtpyymsperihengynfksdiwslgcllyemaalqspfygdk
mnlyslckkieqcdypplpsdhyseelrqlvnmcinpdpekrpdvtyvydvakrmhacta
ss

    Sequence, based on observed residues (ATOM records):
    >6gt1D (D:)
lrpdmgyntlanfriekkigrgqfsevyraaclldgvpvalkkvqifdlmdakaradcik
eidlhkqlnhpnvikfyasfiednelnivleladagdlsrmikhfkkqkrlipertvwky
fvqlcsalehmhsrrvmhrdikpanvfitatgvvklgdtpyymsperihengynfksdiw
slgcllyemaalqspfygdkmnlyslckkieqcdypplpsdhyseelrqlvnmcinpdpe
krpdvtyvydvakrmhacta