PDB entry 6gr2

View 6gr2 on RCSB PDB site
Description: Structure of human galactokinase in complex with galactose and ADP
Class: transferase
Keywords: Leloir pathway, GHMP kinase, galactose, ADP, Structural Genomics, Structural Genomics Consortium, SGC, transferase
Deposited on 2018-06-08, released 2019-06-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2.49 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (Start-398)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6gr2a1, d6gr2a2
  • Chain 'B':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (Start-398)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6gr2b1, d6gr2b2
  • Chain 'C':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (Start-398)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6gr2c1, d6gr2c2
  • Chain 'D':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (Start-398)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6gr2d1, d6gr2d2
  • Chain 'E':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (Start-398)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6gr2e1, d6gr2e2
  • Chain 'F':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (Start-398)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6gr2f1, d6gr2f2
  • Chain 'G':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (Start-398)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6gr2g1, d6gr2g2
  • Chain 'H':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (Start-398)
      • conflict (258-259)
    Domains in SCOPe 2.08: d6gr2h1, d6gr2h2
  • Heterogens: GAL, ADP, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6gr2A (A:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6gr2A (A:)
lrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvl
vgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplp
gfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcg
imdqfislmgqkghallidcrsletslvplsdpklavlitnsnvseypvrrrqceevara
lgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlmve
shrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrhiq
ehyggtatfylsqaadgakvlcl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6gr2B (B:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6gr2B (B:)
qpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvlvg
sprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplpgf
savvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcgim
dqfislmgqkghallidcrsletslvplsdpklavlitnsnvrseypvrrrqceevaral
gaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlmves
hrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrhiqe
hyggtatfylsqaadgakvlcl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6gr2C (C:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6gr2C (C:)
lrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvl
vgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplp
gfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcg
imdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhsseypvrrrqceev
aralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrl
mveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamr
hiqehyggtatfylsqaadgakvlcl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6gr2D (D:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6gr2D (D:)
lrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvl
vgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplp
gfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcg
imdqfislmgqkghallidcrsletslvplsdpklavlitnsnvasseypvrrrqceeva
ralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlm
veshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrh
iqehyggtatfylsqaadgakvlcl

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6gr2E (E:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6gr2E (E:)
rqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvlv
gsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplpg
fsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcgi
mdqfislmgqkghallidcrsletslvplsdpklavlitnsnvasseypvrrrqceevar
algaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlmv
eshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrhi
qehyggtatfylsqaadgakvlcl

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6gr2F (F:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6gr2F (F:)
qpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvlvg
sprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplpgf
savvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcgim
dqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhsseypvrrrqceevar
algaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlmv
eshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrhi
qehyggtatfylsqaadgakvlcl

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6gr2G (G:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6gr2G (G:)
rqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvlv
gsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplpg
fsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcgi
mdqfislmgqkghallidcrsletslvplsdpklavlitnsnseypvrrrqceevaralg
aaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlmvesh
rslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrhiqeh
yggtatfylsqaadgakvlcl

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6gr2H (H:)
mahhhhhhaalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvl
pmalelmtvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgv
iqyypaaplpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqa
ehsfagmpcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslas
seypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaa
alrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctv
tlleasaaphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6gr2H (H:)
qpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvlvg
sprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplpgf
savvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcgim
dqfislmgqkghallidcrsletslvplsdpklavlitnsnvseypvrrrqceevaralg
aaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlmvesh
rslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrhiqeh
yggtatfylsqaadgakvlcl