PDB entry 6goa

View 6goa on RCSB PDB site
Description: Structural basis for OXA-48 dimerization - R189A mutant
Class: hydrolase
Keywords: dimerization, OXA-48, Oxacillinase, carbapenemase, beta-lactamase, ANTIBIOTIC, hydrolase
Deposited on 2018-06-01, released 2018-07-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-11-28, with a file datestamp of 2018-11-23.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6XEC0 (Start-243)
      • engineered mutation (167)
    Domains in SCOPe 2.08: d6goaa_
  • Chain 'B':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6XEC0 (Start-243)
      • engineered mutation (167)
    Domains in SCOPe 2.08: d6goab_
  • Chain 'C':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6XEC0 (Start-243)
      • engineered mutation (167)
    Domains in SCOPe 2.08: d6goac_
  • Chain 'D':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6XEC0 (Start-243)
      • engineered mutation (167)
    Domains in SCOPe 2.08: d6goad_
  • Chain 'E':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6XEC0 (Start-243)
      • engineered mutation (167)
    Domains in SCOPe 2.08: d6goae_
  • Chain 'F':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6XEC0 (Start-243)
      • engineered mutation (167)
    Domains in SCOPe 2.08: d6goaf_
  • Chain 'G':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6XEC0 (Start-243)
      • engineered mutation (167)
    Domains in SCOPe 2.08: d6goag_
  • Chain 'H':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6XEC0 (Start-243)
      • engineered mutation (167)
    Domains in SCOPe 2.08: d6goah_
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6goaA (A:)
gkewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslial
dlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlha
fdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteang
dyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqe
kiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6goaA (A:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6goaB (B:)
gkewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslial
dlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlha
fdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteang
dyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqe
kiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6goaB (B:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6goaC (C:)
gkewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslial
dlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlha
fdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteang
dyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqe
kiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6goaC (C:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6goaD (D:)
gkewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslial
dlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlha
fdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteang
dyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqe
kiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6goaD (D:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6goaE (E:)
gkewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslial
dlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlha
fdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteang
dyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqe
kiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6goaE (E:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6goaF (F:)
gkewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslial
dlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlha
fdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteang
dyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqe
kiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6goaF (F:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6goaG (G:)
gkewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslial
dlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlha
fdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteang
dyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqe
kiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6goaG (G:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6goaH (H:)
gkewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslial
dlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlha
fdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteang
dyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqe
kiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6goaH (H:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqaivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip