PDB entry 6glp
View 6glp on RCSB PDB site
Description: Crystal structure of hMTH1 N33G in complex with LW14 in the presence of acetate
Class: hydrolase
Keywords: Inhibitor, Complex, Hydrolase, DNA repair, Fragment
Deposited on
2018-05-23, released
2019-02-20
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-02-20, with a file datestamp of
2019-02-15.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.48
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: 7,8-dihydro-8-oxoguanine triphosphatase
Species: Homo sapiens [TaxId:9606]
Gene: NUDT1, MTH1
Database cross-references and differences (RAF-indexed):
- Uniprot P36639 (26-End)
- expression tag (24-25)
- engineered mutation (58)
Domains in SCOPe 2.08: d6glpa1, d6glpa2 - Chain 'B':
Compound: 7,8-dihydro-8-oxoguanine triphosphatase
Species: Homo sapiens [TaxId:9606]
Gene: NUDT1, MTH1
Database cross-references and differences (RAF-indexed):
- Uniprot P36639 (26-181)
- expression tag (25)
- engineered mutation (58)
Domains in SCOPe 2.08: d6glpb1, d6glpb2 - Heterogens: BU8, SO4, ACT, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6glpA (A:)
mkhhhhhhpmsdydipttenlyfqgamgasrlytlvlvlqpqrvllgmkkrgfgagrwgg
fggkvqegetiedgarrelqeesgltvdalhkvgqivfefvgepelmdvhvfctdsiqgt
pvesdemrpcwfqldqipfkdmwpddsywfplllqkkkfhgyfkfqgqdtildytlrevd
tv
Sequence, based on observed residues (ATOM records): (download)
>6glpA (A:)
gamgasrlytlvlvlqpqrvllgmkkrgfgagrwggfggkvqegetiedgarrelqeesg
ltvdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwp
ddsywfplllqkkkfhgyfkfqgqdtildytlrev
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6glpB (B:)
mkhhhhhhpmsdydipttenlyfqgamgasrlytlvlvlqpqrvllgmkkrgfgagrwgg
fggkvqegetiedgarrelqeesgltvdalhkvgqivfefvgepelmdvhvfctdsiqgt
pvesdemrpcwfqldqipfkdmwpddsywfplllqkkkfhgyfkfqgqdtildytlrevd
tv
Sequence, based on observed residues (ATOM records): (download)
>6glpB (B:)
amgasrlytlvlvlqpqrvllgmkkrgfgagrwggfggkvqegetiedgarrelqeesgl
tvalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpdd
sywfplllqkkkfhgyfkfqgqdtildytlrevdtv