PDB entry 6glo

View 6glo on RCSB PDB site
Description: Crystal structure of hMTH1 N33G in the presence of acetate
Class: hydrolase
Keywords: Hydrolase, DNA repair
Deposited on 2018-05-23, released 2019-02-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-02-20, with a file datestamp of 2019-02-15.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 7,8-dihydro-8-oxoguanine triphosphatase
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT1, MTH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36639 (26-181)
      • expression tag (25)
      • engineered mutation (58)
    Domains in SCOPe 2.07: d6gloa1, d6gloa2
  • Chain 'B':
    Compound: 7,8-dihydro-8-oxoguanine triphosphatase
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT1, MTH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36639 (26-181)
      • engineered mutation (58)
    Domains in SCOPe 2.07: d6glob_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6gloA (A:)
    mkhhhhhhpmsdydipttenlyfqgamgasrlytlvlvlqpqrvllgmkkrgfgagrwgg
    fggkvqegetiedgarrelqeesgltvdalhkvgqivfefvgepelmdvhvfctdsiqgt
    pvesdemrpcwfqldqipfkdmwpddsywfplllqkkkfhgyfkfqgqdtildytlrevd
    tv
    

    Sequence, based on observed residues (ATOM records): (download)
    >6gloA (A:)
    amgasrlytlvlvlqpqrvllgmkkrgfgagrwggfggkvqegetiedgarrelqeesgl
    tvdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpd
    dsywfplllqkkkfhgyfkfqgqdtildytlrevdtv
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6gloB (B:)
    mkhhhhhhpmsdydipttenlyfqgamgasrlytlvlvlqpqrvllgmkkrgfgagrwgg
    fggkvqegetiedgarrelqeesgltvdalhkvgqivfefvgepelmdvhvfctdsiqgt
    pvesdemrpcwfqldqipfkdmwpddsywfplllqkkkfhgyfkfqgqdtildytlrevd
    tv
    

    Sequence, based on observed residues (ATOM records): (download)
    >6gloB (B:)
    mgasrlytlvlvlqpqrvllgmkkrgfgagrwggfggkvqegetiedgarrelqeesglt
    vdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpdd
    sywfplllqkkkfhgyfkfqgqdtildytlrevdtv