PDB entry 6gko

View 6gko on RCSB PDB site
Description: Mouse thymidylate synthase cocrystallized with dUMP and soaked in phenolphthalein
Class: transferase
Keywords: fragment screening, fragment, inhibitor, TRANSFERASE
Deposited on 2018-05-21, released 2019-06-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-06-05, with a file datestamp of 2019-05-30.
Experiment type: XRAY
Resolution: 1.84 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Tyms
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gkoa_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Tyms
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gkob_
  • Heterogens: UMP, FGT, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6gkoA (A:)
mlvvgselqsdaqqlsaeaprhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsar
qegdlgpvygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkd
lplmalppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpg
dfvhtlgdahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphpt
ikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >6gkoA (A:)
rhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvle
ellwfikgstnakelsskgvriwdangsrdfldslgfsarqegdlgpvygfqwrhfgaey
kdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkdlplmalppchalcqfyvvng
elscqlyqrsgdmglgvpfniasyalltymiahitglqpgdfvhtlgdahiylnhieplk
iqlqreprpfpklkilrkvetiddfkvedfqiegynphptimemav

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6gkoB (B:)
mlvvgselqsdaqqlsaeaprhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsar
qegdlgpvygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkd
lplmalppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpg
dfvhtlgdahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphpt
ikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >6gkoB (B:)
hgelqylrqvehilrcgfkkedrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgvriwdangsrdfldslgfsarqegdlgpvygfqwrhfgaeyk
dmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkdlplmalppchalcqfyvvnge
lscqlyqrsgdmglgvpfniasyalltymiahitglqpgdfvhtlgdahiylnhieplki
qlqreprpfpklkilrkvetiddfkvedfqiegynphptimemav