PDB entry 6gk8

View 6gk8 on RCSB PDB site
Description: crystal structure of anti-tau antibody dmcbtau-28.1, double mutant (s32r, e35k) of cbtau-28.1, in complex with tau peptide a7731 (residues 52-71)
Deposited on 2018-05-18, released 2018-06-13
The last revision was dated 2018-06-13, with a file datestamp of 2018-06-08.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: human fab antibody fragment of cbtau-28.1(s32r;e35k)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6GK8 (0-End)
  • Chain 'I':
    Compound: tau peptide a7731 (residues 52-71)
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6GK8
  • Chain 'L':
    Compound: human fab antibody fragment of cbtau-28.1(s32r;e35k)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6GK8 (0-End)
  • Heterogens: CL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6gk8H (H:)
qvqlqqsgaevkkpgeslkisceasgysftnywigwvrqmpgkglewmgiiypgdsdtry
sppfqgqvtitadrsittaylewsslkasdtamyycarvgrpskggwfdpwgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepksc

    Sequence, based on observed residues (ATOM records):
    >6gk8H (H:)
qvqlqqsgaevkkpgeslkisceasgysftnywigwvrqmpgkglewmgiiypgdsdtry
sppfqgqvtitadrsittaylewsslkasdtamyycarvgrpskggwfdpwgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepk

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6gk8I (I:)
tedgseepgsetsdakstpt

    Sequence, based on observed residues (ATOM records):
    >6gk8I (I:)
eepgsetsdakst

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6gk8L (L:)
diqmtqspdslavslgeratincessqtllyrsnkknylawyqqkpgqppklliswastp
esgvpdrfsgsgsgtsftltisslqaedvavyycqqyynspytfgqgtrleikrtvaaps
vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys
lsstltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >6gk8L (L:)
diqmtqspdslavslgeratincessqtllyrsnkknylawyqqkpgqppklliswastp
esgvpdrfsgsgsgtsftltisslqaedvavyycqqyynspytfgqgtrleikrtvaaps
vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys
lsstltlskadyekhkvyacevthqglsspvtksfnrge