PDB entry 6gju
View 6gju on RCSB PDB site
Description: human NBD1 of CFTR in complex with nanobodies T2a and T4
Class: hydrolase
Keywords: Cystic Fibrosis, CFTR, nanobodies, thermal stabilization, conformational dynamics, hydrolase
Deposited on
2018-05-17, released
2019-06-26
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-08-21, with a file datestamp of
2019-08-16.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cystic fibrosis transmembrane conductance regulator
Species: Homo sapiens [TaxId:9606]
Gene: CFTR
Database cross-references and differences (RAF-indexed):
- Uniprot Q20BJ8
- engineered mutation (106)
- engineered mutation (148)
- engineered mutation (153)
- Chain 'B':
Compound: Nanobody T4
Species: LAMA GLAMA [TaxId:9844]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6gjub1, d6gjub2 - Chain 'C':
Compound: Nanobody T2a
Species: LAMA GLAMA [TaxId:9844]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6gjuc1, d6gjuc2 - Heterogens: GOL, PEG, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6gjuB (B:)
qvqlqesggglvqaggslrlscaasgstfaiiamgwyrqapgkqrelvavistgdtryad
svkgrftisrdnakntvylqmdslrpedtavyycnaavqvrdyrnywgqgtqvtvssaaa
hhhhhhgaaeqkliseedlngaa
Sequence, based on observed residues (ATOM records): (download)
>6gjuB (B:)
qvqlqesggglvqaggslrlscaasgstfaiiamgwyrqapgkqrelvavistgdtryad
svkgrftisrdnakntvylqmdslrpedtavyycnaavqvrdyrnywgqgtqvtvssa
- Chain 'C':
Sequence, based on SEQRES records: (download)
>6gjuC (C:)
qvqlqesggglvqaggslrlscaasgsifridamgwyrqapgkqrelvahstsggstdya
dsvkgrftisrdnakntvylqmnslkpedtavyycnadvrtrwyasnnywgqgtqvtvss
aaahhhhhhgaaeqkliseedlngaa
Sequence, based on observed residues (ATOM records): (download)
>6gjuC (C:)
qvqlqesggglvqaggslrlscaasgsifridamgwyrqapgkqrelvahstsggstdya
dsvkgrftisrdnakntvylqmnslkpedtavyycnadvrtrwyasnnywgqgtqvtvss