PDB entry 6gjs

View 6gjs on RCSB PDB site
Description: Human NBD1 of CFTR in complex with nanobodies D12 and T4
Class: immune system
Keywords: Cystic Fibrosis, CFTR, nanobodies, thermal stabilization, conformational dynamics, immune system
Deposited on 2018-05-16, released 2019-06-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-06-26, with a file datestamp of 2019-06-21.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q20BJ8 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d6gjsa1, d6gjsa2
  • Chain 'B':
    Compound: Nanobody D12
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6GJS (0-End)
    Domains in SCOPe 2.08: d6gjsb1, d6gjsb2
  • Chain 'C':
    Compound: Nanobody T4
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6GJS (0-End)
    Domains in SCOPe 2.08: d6gjsc1, d6gjsc2
  • Heterogens: MG, ATP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6gjsA (A:)
sltttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmmimgelep
segkikhsgrisfcsqfswimpgtikeniifgvsydeyryrsvikacqleediskfaekd
nivlgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklman
ktrilvtskmehlkkadkililhegssyfygtfselqnlqpdfssklmg

    Sequence, based on observed residues (ATOM records): (download) 
    >6gjsA (A:)
sltttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmmimgelep
segkikhsgrisfcsqfswimpgtikeniifgvsydeyryrsvikacqleediskfaekd
nivlgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklman
ktrilvtskmehlkkadkililhegssyfygtfselqnl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6gjsB (B:)
qvqlqesggglvqagsslrlacaatgsirsinnmgwyrqapgkqrgmvaiitrvgntdya
dsvkgrftisrdnakntvylqmnslkpedtatyychaeiteqsrpfyltddywgqgtqvt
vssaaahhhhhhgaaeqkliseedlngaa

    Sequence, based on observed residues (ATOM records): (download) 
    >6gjsB (B:)
qvqlqesggglvqagsslrlacaatgsirsinnmgwyrqapgkqrgmvaiitrvgntdya
dsvkgrftisrdnakntvylqmnslkpedtatyychaeiteqsrpfyltddywgqgtqvt
vs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6gjsC (C:)
qvqlqesggglvqaggslrlscaasgstfaiiamgwyrqapgkqrelvavistgdtryad
svkgrftisrdnakntvylqmdslrpedtavyycnaavqvrdyrnywgqgtqvtvssaaa
hhhhhhgaaeqkliseedlngaa

    Sequence, based on observed residues (ATOM records): (download) 
    >6gjsC (C:)
qvqlqesggglvqaggslrlscaasgstfaiiamgwyrqapgkqrelvavistgdtryad
svkgrftisrdnakntvylqmdslrpedtavyycnaavqvrdyrnywgqgtqvtvss