PDB entry 6gin

View 6gin on RCSB PDB site
Description: Crystal structure of the ACVR1 (ALK2) kinase in complex with an Quinazolinone based ALK2 inhibitor with a 4-morpholinophenyl solvent accessible group.
Class: signaling protein
Keywords: Kinase, BMP, inhibitor, signalling, SIGNALING PROTEIN
Deposited on 2018-05-14, released 2018-05-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-03, with a file datestamp of 2019-03-29.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Activin receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR1, ACVRLK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04771 (Start-300)
      • engineered mutation (8)
    Domains in SCOPe 2.08: d6gina_
  • Chain 'B':
    Compound: Activin receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR1, ACVRLK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04771 (Start-300)
      • engineered mutation (8)
    Domains in SCOPe 2.08: d6ginb_
  • Heterogens: IR2, SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ginA (A:)
smqrtvarditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlr
henilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglah
lhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgt
krymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpnd
psfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki
d

    Sequence, based on observed residues (ATOM records): (download) 
    >6ginA (A:)
varditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlrhenil
gfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglahlhiei
fgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgtkryma
pevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpndpsfed
mrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltkid

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ginB (B:)
smqrtvarditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlr
henilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglah
lhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgt
krymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpnd
psfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki
d

    Sequence, based on observed residues (ATOM records): (download) 
    >6ginB (B:)
varditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlrhenil
gfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglahlhiei
fgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgtkryma
pevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpndpsfed
mrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltkid