PDB entry 6ghg

View 6ghg on RCSB PDB site
Description: Variable heavy - variable light domain and Fab-arm CrossMabs with charged residue exchanges
Class: immune system
Keywords: antibody, fab fragment, dp47, ang2, vegf, crossmab, charge variants, immune system
Deposited on 2018-05-07, released 2018-09-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-12-05, with a file datestamp of 2018-11-30.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6GHG (0-End)
    Domains in SCOPe 2.08: d6ghga_
  • Chain 'B':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6GHG (0-End)
    Domains in SCOPe 2.08: d6ghgb_
  • Chain 'H':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6GHG (0-End)
    Domains in SCOPe 2.08: d6ghgh_
  • Chain 'L':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6GHG (0-214)
    Domains in SCOPe 2.08: d6ghgl_
  • Heterogens: NA, P6G, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ghgA (A:)
evqllesggglvqpggslrlscaasgftfssyamswvrqapgkglewvsaisgsggstyy
adsvkgrftisrdnskntlylqmnslraedtavyycakgsgfdywgqgtlvtvssastkg
psvfplapsskstsggtaalgclvedyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdekvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >6ghgA (A:)
evqllesggglvqpggslrlscaasgftfssyamswvrqapgkglewvsaisgsggstyy
adsvkgrftisrdnskntlylqmnslraedtavyycakgsgfdywgqgtlvtvssastkg
psvfplapsskstsggtaalgclvedyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdekvepks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ghgB (B:)
eivltqspgtlslspgeratlscrasqsvsssylawyqqkpgqaprlliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqygsspltfgqgtkveikrtvaapsvfifp
psdkklksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6ghgB (B:)
eivltqspgtlslspgeratlscrasqsvsssylawyqqkpgqaprlliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqygsspltfgqgtkveikrtvaapsvfifp
psdkklksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6ghgH (H:)
evqllesggglvqpggslrlscaasgftfssyamswvrqapgkglewvsaisgsggstyy
adsvkgrftisrdnskntlylqmnslraedtavyycakgsgfdywgqgtlvtvssastkg
psvfplapsskstsggtaalgclvedyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdekvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >6ghgH (H:)
evqllesggglvqpggslrlscaasgftfssyamswvrqapgkglewvsaisgsggstyy
adsvkgrftisrdnskntlylqmnslraedtavyycakgsgfdywgqgtlvtvssastkg
psvfplapsgtaalgclvedyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtv
pssslgtqtyicnvnhkpsntkvdekvepks

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ghgL (L:)
eivltqspgtlslspgeratlscrasqsvsssylawyqqkpgqaprlliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqygsspltfgqgtkveikrtvaapsvfifp
psdkklksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec