PDB entry 6ghd

View 6ghd on RCSB PDB site
Description: Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases
Class: protein binding
Keywords: nuclear envelope, gene expression, ternary complex, PROTEIN BINDING
Deposited on 2018-05-07, released 2018-08-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-08-08, with a file datestamp of 2018-08-03.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: barrier-to-autointegration factor
    Species: Homo sapiens [TaxId:9606]
    Gene: BANF1, BAF, BCRG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75531 (0-87)
      • engineered mutation (65)
      • engineered mutation (75)
      • engineered mutation (78)
      • engineered mutation (83)
    Domains in SCOPe 2.07: d6ghda_
  • Chain 'B':
    Compound: Prelamin-A/C
    Species: Homo sapiens [TaxId:9606]
    Gene: LMNA, LMN1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6ghdb_
  • Chain 'C':
    Compound: barrier-to-autointegration factor
    Species: Homo sapiens [TaxId:9606]
    Gene: BANF1, BAF, BCRG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75531 (Start-87)
      • engineered mutation (65)
      • engineered mutation (75)
      • engineered mutation (78)
      • engineered mutation (83)
    Domains in SCOPe 2.07: d6ghdc_
  • Chain 'D':
    Compound: barrier-to-autointegration factor
    Species: Homo sapiens [TaxId:9606]
    Gene: BANF1, BAF, BCRG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75531 (Start-87)
      • engineered mutation (65)
      • engineered mutation (75)
      • engineered mutation (78)
      • engineered mutation (83)
    Domains in SCOPe 2.07: d6ghdd_
  • Chain 'E':
    Compound: barrier-to-autointegration factor
    Species: Homo sapiens [TaxId:9606]
    Gene: BANF1, BAF, BCRG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75531 (0-87)
      • engineered mutation (65)
      • engineered mutation (75)
      • engineered mutation (78)
      • engineered mutation (83)
    Domains in SCOPe 2.07: d6ghde_
  • Chain 'F':
    Compound: Prelamin-A/C
    Species: Homo sapiens [TaxId:9606]
    Gene: LMNA, LMN1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6ghdf_
  • Chain 'G':
    Compound: emerin
    Species: Homo sapiens [TaxId:9606]
    Gene: EMD, EDMD, STA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P50402 (1-44)
      • expression tag (0)
    Domains in SCOPe 2.07: d6ghdg1, d6ghdg2
  • Chain 'H':
    Compound: emerin
    Species: Homo sapiens [TaxId:9606]
    Gene: EMD, EDMD, STA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6ghdh_
  • Heterogens: SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ghdA (A:)
ttsqkhrdfvaepmgekpvgslagigevlgkkleergfdkayvvlgqflvlkkdedlfre
wlkdtaganakqsrdafgalrewadafl

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ghdB (B:)
ssfsqhartsgrvaveevdeegkfvrlrnksnedqsmgnwqikrqngddplltyrfppkf
tlkagqvvtiwaagagathspptdlvwkaqntwgcgnslrtalinstgeevamrklvrs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6ghdC (C:)
ttsqkhrdfvaepmgekpvgslagigevlgkkleergfdkayvvlgqflvlkkdedlfre
wlkdtaganakqsrdafgalrewadafl

    Sequence, based on observed residues (ATOM records): (download) 
    >6ghdC (C:)
tsqkhrdfvaepmgekpvgslagigevlgkkleergfdkayvvlgqflvlkkdedlfrew
lkdtaganakqsrdafgalrewadafl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6ghdD (D:)
ttsqkhrdfvaepmgekpvgslagigevlgkkleergfdkayvvlgqflvlkkdedlfre
wlkdtaganakqsrdafgalrewadafl

    Sequence, based on observed residues (ATOM records): (download) 
    >6ghdD (D:)
tsqkhrdfvaepmgekpvgslagigevlgkkleergfdkayvvlgqflvlkkdedlfrew
lkdtaganakqsrdafgalrewadafl

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ghdE (E:)
ttsqkhrdfvaepmgekpvgslagigevlgkkleergfdkayvvlgqflvlkkdedlfre
wlkdtaganakqsrdafgalrewadafl

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6ghdF (F:)
ssfsqhartsgrvaveevdeegkfvrlrnksnedqsmgnwqikrqngddplltyrfppkf
tlkagqvvtiwaagagathspptdlvwkaqntwgcgnslrtalinstgeevamrklvrs

    Sequence, based on observed residues (ATOM records): (download) 
    >6ghdF (F:)
sfsqhartsgrvaveevdeegkfvrlrnksnedqsmgnwqikrqngddplltyrfppkft
lkagqvvtiwaagagathspptdlvwkaqntwgcgnslrtalinstgeevamrklvrs

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ghdG (G:)
gdnyadlsdtelttllrryniphgpvvgstrrlyekkifeyetqr

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6ghdH (H:)
gdnyadlsdtelttllrryniphgpvvgstrrlyekkifeyetqr

    Sequence, based on observed residues (ATOM records): (download) 
    >6ghdH (H:)
dnyadlsdtelttllrryniphgpvvgstrrlyekkifeyetq