PDB entry 6gh9

View 6gh9 on RCSB PDB site
Description: USP15 catalytic domain in complex with small molecule
Class: hydrolase
Keywords: protease, ubiquitin, ubiquitin specific protease, inhibitor, mitoxantrone, hydrolase
Deposited on 2018-05-06, released 2018-09-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-11-21, with a file datestamp of 2018-11-16.
Experiment type: XRAY
Resolution: 2.09 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ubiquitin carboxyl-terminal hydrolase 15
    Species: Homo sapiens [TaxId:9606]
    Gene: USP15, KIAA0529
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y4E8 (1-185)
      • initiating methionine (0)
      • linker (186)
      • linker (189-190)
    • Uniprot Q9Y4E8 (191-End)
    Domains in SCOPe 2.08: d6gh9a_
  • Chain 'B':
    Compound: ubiquitin carboxyl-terminal hydrolase 15
    Species: Homo sapiens [TaxId:9606]
    Gene: USP15, KIAA0529
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y4E8 (1-185)
      • initiating methionine (0)
      • linker (187-190)
      • linker (186)
    • Uniprot Q9Y4E8 (191-End)
    Domains in SCOPe 2.08: d6gh9b_
  • Heterogens: ZN, DMS, MIX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6gh9A (A:)
meqpglcglsnlgntcfmnsaiqclsntpplteyflndkyqeelnfdnplgmrgeiaksy
aelikqmwsgkfsyvtprafktqvgrfapqfsgyqqqdcqellaflldglhedlnrirkk
pyiqlkdadgrpdkvvaeeawenhlkrndsiivdifhglfkstlvcpecakisvtfdpfc
yltlplastskvklkdcielfttkeklgaedpwycpnckehqqatkkldlwslppvlvvh
lkrfsysrymrdkldtlvdfpindldmseflinpnagpcrynliavsnhyggmggghyta
faknkddgkwyyfddssvstasedqivskaayvlfyqrqdtfsgtgffpldretaaaleh
hhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6gh9A (A:)
meqpglcglsnlgntcfmnsaiqclsntpplteyflndkyqeelnfdnplgmrgeiaksy
aelikqmwsgkfsyvtprafktqvgrfapqqellaflldglhedlnrirkkpyiqlkdad
grpdkvvaeeawenhlkrndsiivdifhglfkstlvcpecakisvtfdpfcyltlplask
vklkdcielfttkeklgaedpwycpnckehqqatkkldlwslppvlvvhlkrfsdkldtl
vdfpindldmseflinpnagpcrynliavsnhyggmggghytafaknkddgkwyyfddss
vstasedqivskaayvlfyqrqdtfsgtgff

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6gh9B (B:)
meqpglcglsnlgntcfmnsaiqclsntpplteyflndkyqeelnfdnplgmrgeiaksy
aelikqmwsgkfsyvtprafktqvgrfapqfsgyqqqdcqellaflldglhedlnrirkk
pyiqlkdadgrpdkvvaeeawenhlkrndsiivdifhglfkstlvcpecakisvtfdpfc
yltlplastskvklkdcielfttkeklgaedpwycpnckehqqatkkldlwslppvlvvh
lkrfsysrymrdkldtlvdfpindldmseflinpnagpcrynliavsnhyggmggghyta
faknkddgkwyyfddssvstasedqivskaayvlfyqrqdtfsgtgffpldretaaaleh
hhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6gh9B (B:)
meqpglcglsnlgntcfmnsaiqclsntpplteyflndkyqeelnfdnplgmrgeiaksy
aelikqmwsgkfsyvtprafktqvgrfapqqellaflldglhedlnrirkkpyiqlkdad
grpdkvvaeeawenhlkrndsiivdifhglfkstlvcpecakisvtfdpfcyltlplast
skvklkdcielfttkekatkkldlwslppvlvvhlkrfsdkldtlvdfpindldmsefli
npnagpcrynliavsnhyghytafaknkddgkwyyfddssvstasedqivskaayvlfyq
rqdtfsgtg