PDB entry 6ggd
View 6ggd on RCSB PDB site
Description: p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9324
Class: DNA binding protein
Keywords: p53, transcription factor, tumor supressor, cancer therapy, oncogenic mutant, protein misfolding, small-molecule stabilizer, molecular chaperone, DNA BINDING PROTEIN
Deposited on
2018-05-03, released
2019-05-22
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-10-30, with a file datestamp of
2019-10-25.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.53
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Gene: TP53, P53
Database cross-references and differences (RAF-indexed):
- Uniprot P04637
- engineered mutation (39)
- engineered mutation (109)
- engineered mutation (126)
- engineered mutation (145)
- engineered mutation (174)
Domains in SCOPe 2.08: d6ggda_ - Chain 'B':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Gene: TP53, P53
Database cross-references and differences (RAF-indexed):
- Uniprot P04637 (0-End)
- engineered mutation (39)
- engineered mutation (109)
- engineered mutation (126)
- engineered mutation (145)
- engineered mutation (174)
Domains in SCOPe 2.08: d6ggdb_ - Heterogens: ZN, EYB, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6ggdA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt
Sequence, based on observed residues (ATOM records): (download)
>6ggdA (A:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfrhs
vvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevrvc
acpgrdrrteeenlrk
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6ggdB (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt
Sequence, based on observed residues (ATOM records): (download)
>6ggdB (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdrrteeenlrk