PDB entry 6gfx

View 6gfx on RCSB PDB site
Description: pvhl:elob:eloc in complex with modified hif-1a codd peptide containing (3r,4s)-3-fluoro-4-hydroxyproline (ligand 13a)
Deposited on 2018-05-02, released 2018-07-11
The last revision was dated 2018-08-01, with a file datestamp of 2018-07-27.
Experiment type: XRAY
Resolution: 1.83 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Elongin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOB, TCEB2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Elongin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOC, TCEB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15369 (1-96)
      • initiating methionine (0)
  • Chain 'C':
    Compound: von hippel-lindau disease tumor suppressor
    Species: Homo sapiens [TaxId:9606]
    Gene: VHL
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: fluorinated hypoxia-inducible factor 1 alpha peptide
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6GFX
  • Heterogens: EX8, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records:
    >6gfxA (A:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmk

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6gfxB (B:)
mmyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc

    Sequence, based on observed residues (ATOM records):
    >6gfxB (B:)
mmyvklissdghefivkrehaltsgtikamlsgnevnfreipshvlskvcmyftykvryt
nssteipefpiapeialellmaanfldc

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6gfxC (C:)
meagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyr
ghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpe
nyrrldivrslyedledhpnvqkdlerltqeriahqrmgd

    Sequence, based on observed residues (ATOM records):
    >6gfxC (C:)
pvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfr
dagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldi
vrslyedledhpnvqkdlerltqeria

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6gfxD (D:)
dealaxyipmdddfqlrsf

    Sequence, based on observed residues (ATOM records):
    >6gfxD (D:)
ealaxyipmdddfqlr