PDB entry 6gfi
View 6gfi on RCSB PDB site
Description: Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V
Class: protein binding
Keywords: protein protein interactions, serine proteases, amyloid protein precursor inhibitor, protein binding
Deposited on
2018-04-30, released
2018-09-12
The last revision prior to the SCOPe 2.08 freeze date was dated
2018-10-10, with a file datestamp of
2018-10-05.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.23
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: PRSS3 protein
Species: Homo sapiens [TaxId:9606]
Gene: PRSS3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6gfia_ - Chain 'B':
Compound: PRSS3 protein
Species: Homo sapiens [TaxId:9606]
Gene: PRSS3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6gfib_ - Chain 'C':
Compound: Amyloid-beta A4 protein
Species: Homo sapiens [TaxId:9606]
Gene: APP, A4, AD1
Database cross-references and differences (RAF-indexed):
- Uniprot P05067 (17-End)
- expression tag (11-16)
- engineered mutation (20)
- conflict (26-27)
- conflict (43)
Domains in SCOPe 2.08: d6gfic1, d6gfic2 - Chain 'E':
Compound: Amyloid-beta A4 protein
Species: Homo sapiens [TaxId:9606]
Gene: APP, A4, AD1
Database cross-references and differences (RAF-indexed):
- Uniprot P05067 (17-End)
- expression tag (11-16)
- engineered mutation (20)
- conflict (26-27)
- conflict (43)
Domains in SCOPe 2.08: d6gfie1, d6gfie2 - Heterogens: EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>6gfiA (A:)
ivggytceenslpyqvslnsgshfcggsliseqwvvsaahcyktriqvrlgehnikvleg
neqfinaakiirhpkynrdtldndimliklsspavinarvstislptappaagteclisg
wgntlsfgadypdelkcldapvltqaeckasypgkitnsmfcvgfleggkdscqrdaggp
vvcngqlqgvvswghgcawknrpgvytkvynyvdwikdtiaans
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>6gfiB (B:)
ivggytceenslpyqvslnsgshfcggsliseqwvvsaahcyktriqvrlgehnikvleg
neqfinaakiirhpkynrdtldndimliklsspavinarvstislptappaagteclisg
wgntlsfgadypdelkcldapvltqaeckasypgkitnsmfcvgfleggkdscqrdaggp
vvcngqlqgvvswghgcawknrpgvytkvynyvdwikdtiaans
- Chain 'C':
Sequence, based on SEQRES records: (download)
>6gfiC (C:)
yvdykddddkevevcseqaevgpcrarfsrwyfdvtegkcapfvyggcggnrnnfdteey
cmavcgsaiprhhhhhhaaan
Sequence, based on observed residues (ATOM records): (download)
>6gfiC (C:)
vevcseqaevgpcrarfsrwyfdvtegkcapfvyggcggnrnnfdteeycmavcgs
- Chain 'E':
Sequence, based on SEQRES records: (download)
>6gfiE (E:)
yvdykddddkevevcseqaevgpcrarfsrwyfdvtegkcapfvyggcggnrnnfdteey
cmavcgsaiprhhhhhhaaan
Sequence, based on observed residues (ATOM records): (download)
>6gfiE (E:)
vevcseqaevgpcrarfsrwyfdvtegkcapfvyggcggnrnnfdteeycmavcgs