PDB entry 6gek

View 6gek on RCSB PDB site
Description: tead4 (216-434);y429f complexed with yap peptide (60-100) and myristoate (covalently bound) at 2.28a (p212121 crystal form); myristoylation was done by adding myr-coa
Deposited on 2018-04-26, released 2018-09-19
The last revision was dated 2018-10-31, with a file datestamp of 2018-10-26.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transcriptional enhancer factor TEF-3
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD4, RTEF1, TCF13L1, TEF3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15561 (Start-218)
      • engineered mutation (213)
  • Chain 'B':
    Compound: Transcriptional enhancer factor TEF-3
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD4, RTEF1, TCF13L1, TEF3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15561 (Start-218)
      • engineered mutation (213)
  • Chain 'L':
    Compound: Transcriptional coactivator YAP1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: Transcriptional coactivator YAP1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: MYR, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6gekA (A:)
grsvassklwmlefsafleqqqdpdtynkhlfvhigqsspsysdpyleavdirqiydkfp
ekkgglkdlfergpsnafflvkfwadlntniedegssfygvssqyespenmiitcstkvc
sfgkqvvekveteyaryenghysyrihrsplceyminfihklkhlpekymmnsvlenfti
lqvvtnrdtqetllciayvfevsasehgaqhhifrlvke

    Sequence, based on observed residues (ATOM records):
    >6gekA (A:)
rsvassklwmlefsafleqqqdpdtynkhlfvhigleavdirqiydkfpekkgglkdlfe
rgpsnafflvkfwadlntssfygvssqyespenmiitcstkvcsfgkqvvekveteyary
enghysyrihrsplceyminfihklkhlpekymmnsvlenftilqvvtnrdtqetllcia
yvfevsasehgaqhhifrlvke

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6gekB (B:)
grsvassklwmlefsafleqqqdpdtynkhlfvhigqsspsysdpyleavdirqiydkfp
ekkgglkdlfergpsnafflvkfwadlntniedegssfygvssqyespenmiitcstkvc
sfgkqvvekveteyaryenghysyrihrsplceyminfihklkhlpekymmnsvlenfti
lqvvtnrdtqetllciayvfevsasehgaqhhifrlvke

    Sequence, based on observed residues (ATOM records):
    >6gekB (B:)
rsvassklwmlefsafleqqqdpdtynkhlfvhigqsssdpyleavdirqiydkfpekkg
glkdlfergpsnafflvkfwadlntngssfygvssqyespenmiitcstkvcsfgkqvve
kveteyaryenghysyrihrsplceyminfihklkhlpekymmnsvlenftilqvvtnrd
tqetllciayvfevsahgaqhhifrlvke

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6gekL (L:)
dsetdlealfnavmnpktanvpqtvpmrlrklpdsffkppe

    Sequence, based on observed residues (ATOM records):
    >6gekL (L:)
dsetdlealfnavmnpqtvpmrlrklpdsffkpp

  • Chain 'M':
    Sequence, based on SEQRES records:
    >6gekM (M:)
dsetdlealfnavmnpktanvpqtvpmrlrklpdsffkppe

    Sequence, based on observed residues (ATOM records):
    >6gekM (M:)
etdlealfnavmntvpmrlrklpdsffkpp