PDB entry 6gdq
View 6gdq on RCSB PDB site
Description: Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2
Class: signaling protein
Keywords: Erk2 Kinase inhibitor, SIGNALING PROTEIN
Deposited on
2018-04-24, released
2018-05-30
The last revision prior to the SCOPe 2.08 freeze date was dated
2018-06-27, with a file datestamp of
2018-06-22.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: N/A
AEROSPACI score: 0.35
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Mitogen-activated protein kinase 1
Species: Homo sapiens [TaxId:9606]
Gene: MAPK1, ERK2, PRKM1, PRKM2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6gdqa_ - Heterogens: EVK, SO4, DMS, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6gdqA (A:)
mahhhhhhmaaaaaagagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrva
ikkispfehqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdl
ykllktqhlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglar
vadpdhdhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkh
yldqlnhilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldk
mltfnphkrieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeeta
rfqpgyrs
Sequence, based on observed residues (ATOM records): (download)
>6gdqA (A:)
gpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtl
reikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyf
lyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyva
trwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsq
edlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqala
hpyleqyydpsdepiaeapfkpkeklkelifeetarfqpg