PDB entry 6gdg

View 6gdg on RCSB PDB site
Description: cryo-em structure of the adenosine a2a receptor bound to a minigs heterotrimer
Deposited on 2018-04-23, released 2018-05-16
The last revision was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: EM
Resolution: 4.11 Å
R-factor: N/A
AEROSPACI score: 0.04 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: TrxA,Adenosine receptor A2a
    Species: Homo sapiens [TaxId:9606]
    Gene: ADORA2A, ADORA2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAS, GNAS1, GSP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63092
      • conflict (43-44)
    • Uniprot P63092 (Start-247)
      • conflict (112)
      • conflict (115)
      • conflict (225)
      • conflict (228)
  • Chain 'E':
    Compound: nanobody Nb35
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6GDG
  • Heterogens: NEC

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6gdgA (A:)
mllvnqshqgfnkehtskmvsaivlyvllaaaahsafaahhhhhhhhhhenlyfqgsdki
ihltddsfdtdvlkadgailvdfwaewsgpskmiapildeiadeyqgkltvaklnidqnp
gtapkygirgiptlllfangevaatkvgalskgqlkefldanlaeaaakavyitvelaia
vlailgnvlvcwavwlnsnlqnvtnyfvvslaaadiavgvlaipfaitistgfcaachgc
lfiacfvlvltqssifsllaiaidryiairiplrynglvtgtrakgiiaicwvlsfaigl
tpmlgwnncgqpkegkahsqgcgegqvaclfedvvpmnymvyfnffacvlvplllmlgvy
lriflaarrqlkqmesqplpgerarstlqkevhaakslaiivglfalcwlplhiincftf
fcpdcshaplwlmylaivlshtnsvvnpfiyayrirefrqtfrkiirshvlrqqepfka

    Sequence, based on observed residues (ATOM records):
    >6gdgA (A:)
avyitvelaiavlailgnvlvcwavwlnsnlqnvtnyfvvslaaadiavgvlaipfaiti
stgfcaachgclfiacfvlvltqssifsllaiaidryiairiplrynglvtgtrakgiia
icwvlsfaigltpmlgwnncvaclfedvvpmnymvyfnffacvlvplllmlgvylrifla
arrqlkqmtlqkevhaakslaiivglfalcwlplhiincftffcpdcshaplwlmylaiv
lshtnsvvnpfiyayrirefrqtf

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6gdgB (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records):
    >6gdgB (B:)
dqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamhwg
tdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnicsiy
nlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftght
gdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafatg
sddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalkadr
agvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6gdgC (C:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffsail

    Sequence, based on observed residues (ATOM records):
    >6gdgC (C:)
qarklveqlkmeanidrikvskaaadlmayceahakedplltpv

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6gdgD (D:)
nsktedqrneekaqreankkiekqlqkdkqvyrathrllllgadnsgkstivkqmrilhg
gsggsggtsgifetkfqvdkvnfhmfdvggqrderrkwiqcfndvtaiifvvdssdynrl
qealnlfksiwnnrwlrtisvilflnkqdllaekvlagkskiedyfpefaryttpedatp
epgedprvtrakyfirdeflristasgdgrhycyphftcavdtenarrifndcrdiiqrm
hlrqyell

    Sequence, based on observed residues (ATOM records):
    >6gdgD (D:)
qrneekaqreankkiekqlqkdkqvyrathrllllgadnsgkstivgifetkfqvdkvnf
hmfdvggqrderrkwiqcfndvtaiifvvdssdynrlqealnlfksiwnnrwlrtisvil
flnkqdllaekvlagkskiedyfpefaryttpedatpepgedprvtrakyfirdeflris
tasgdgrhycyphftcavdtenarrifndcrdiiqrmhlrqyell

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6gdgE (E:)
mkyllptaaagllllaaqpamaqvqlqesggglvqpggslrlscaasgftfsnykmnwvr
qapgkglewvsdisqsgasisytgsvkgrftisrdnakntlylqmnslkpedtavyycar
cpapftrdcfdvtsttyayrgqgtqvtvsshhhhhh

    Sequence, based on observed residues (ATOM records):
    >6gdgE (E:)
qvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasisy
tgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrgq
gtqvtvss