PDB entry 6gbt

View 6gbt on RCSB PDB site
Description: 17beta-hydroxysteroid dehydrogenase type 14 Mutant Y253A in complex with a non-steroidal inhibitor
Class: oxidoreductase
Keywords: Inhibitor Complex mutant, OXIDOREDUCTASE
Deposited on 2018-04-16, released 2019-04-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-24, with a file datestamp of 2019-04-19.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 17-beta-hydroxysteroid dehydrogenase 14
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD17B14, DHRS10, SDR3, SDR47C1, UNQ502/PRO474
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BPX1
      • conflict (204)
      • engineered mutation (254)
    Domains in SCOPe 2.08: d6gbta_
  • Heterogens: NAD, F45, DMS, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6gbtA (A:)
matgtryagkvvvvtgggrgigagivrafvnsgarvvicdkdesggraleqelpgavfil
cdvtqeddvktlvsetirrfgrldcvvnnaghhpppqrpeetsaqgfrqllelnllgtyt
ltklalpylrksqgnvinisslvgaigqaqavpyvatkgavtamtkalaldespygvrvn
cispgniwtplweelaalmpdprasiregmlaqplgrmgqpaevgaaavflaseanfctg
iellvtggaelgygakasrstpvdapdips

    Sequence, based on observed residues (ATOM records): (download) 
    >6gbtA (A:)
tryagkvvvvtgggrgigagivrafvnsgarvvicdkdesggraleqelpgavfilcdvt
qeddvktlvsetirrfgrldcvvnnaghhpppqrpeetsaqgfrqllelnllgtytltkl
alpylrksqgnvinisslvgaigqaqavpyvatkgavtamtkalaldespygvrvncisp
gniwtplweelaalmpdprasiregmlaqplgrmgqpaevgaaavflaseanfctgiell
vtggaelgygakasr