PDB entry 6g9o

View 6g9o on RCSB PDB site
Description: structure of full-length homomeric mlrrc8a volume-regulated anion channel at 4.25 a resolution
Deposited on 2018-04-11, released 2018-05-16
The last revision was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: EM
Resolution: 4.25 Å
R-factor: N/A
AEROSPACI score: 0.06 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Volume-regulated anion channel subunit LRRC8A
    Species: Mus musculus [TaxId:10090]
    Gene: Lrrc8a, Lrrc8
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Volume-regulated anion channel subunit LRRC8A
    Species: Mus musculus [TaxId:10090]
    Gene: Lrrc8a, Lrrc8
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Volume-regulated anion channel subunit LRRC8A
    Species: Mus musculus [TaxId:10090]
    Gene: Lrrc8a, Lrrc8
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Volume-regulated anion channel subunit LRRC8A
    Species: Mus musculus [TaxId:10090]
    Gene: Lrrc8a, Lrrc8
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Volume-regulated anion channel subunit LRRC8A
    Species: Mus musculus [TaxId:10090]
    Gene: Lrrc8a, Lrrc8
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Volume-regulated anion channel subunit LRRC8A
    Species: Mus musculus [TaxId:10090]
    Gene: Lrrc8a, Lrrc8
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6g9oA (A:)
mipvtelryfadtqpayrilkpwwdvftdyisivmlmiavfggtlqvtqdkmiclpckwv
tkdscndsfrgwaasspeptypnstvlptpdtgptgikydldrhqynyvdavcyenrlhw
fakyfpylvllhtliflacsnfwfkfprtssklehfvsillkcfdspwttralsetvvee
sdpkpafskmngsmdkksstvsedveatvpmlqrtksrieqgivdrsetgvldkkegeqa
kalfekvkkfrthveegdivyrlymrqtiikvikfaliicytvyyvhnikfdvdctvdie
sltgyrtyrcahplatlfkilasfyislvifyglicmytlwwmlrrslkkysfesirees
sysdipdvkndfafmlhlidqydplyskrfavflsevsenklrqlnlnnewtldklrqrl
tknaqdklelhlfmlsgipdtvfdlvelevlklelipdvtippsiaqltglkelwlyhta
akieapalaflrenlralhikftdikeiplwiyslktleelhltgnlsaennryividgl
relkrlkvlrlksnlsklpqvvtdvgvhlqklsinnegtklivlnslkkmvnltelelir
cdleriphsifslhnlqeidlkdnnlktieeiisfqhlhrltclklwynhiayipiqign
ltnlerlylnrnkiekiptqlfycrklryldlshnnltflpadigllqnlqnlavtanri
ealppelfqcrklralhlgnnvlqslpsrvgeltnltqielrgnrleclpvelgecpllk
rsglvveedlfstlppevkerlwradkeqa

    Sequence, based on observed residues (ATOM records):
    >6g9oA (A:)
payrilkpwwdvftdyisivmlmiavfggtlqvtqdkmiclpckwvtkdscndstgptgi
kydldrhqynyvdavcyenrlhwfakyfpylvllhtliflacsnfwfkfprtssklehfv
sillkcfdspwttralsetgvldkkegeqakalfekvkkfrthveegdivyrlymrqtii
kvikfaliicytvyyvhnikfdvdctvdiesltgyrtyrcahplatlfkilasfyislvi
fyglicmytlwwmlrrslkkysfesireessysdipdvkndfafmlhlidqydplyskrf
avflsevsenklrqlnlnnewtldklrqrltknaqdklelhlfmlsgipdtvfdlvelev
lklelipdvtippsiaqltglkelwlyhtaakieapalaflrenlralhikftdikeipl
wiyslktleelhltgnlsaennryividglrelkrlkvlrlksnlsklpqvvtdvgvhlq
klsinnegtklivlnslkkmvnltelelircdleriphsifslhnlqeidlkdnnlktie
eiisfqhlhrltclklwynhiayipiqignltnlerlylnrnkiekiptqlfycrklryl
dlshnnltflpadigllqnlqnlavtanriealppelfqcrklralhlgnnvlqslpsrv
geltnltqielrgnrleclpvelgecpllkrsglvveedlfstlppevkerlwradke

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6g9oB (B:)
mipvtelryfadtqpayrilkpwwdvftdyisivmlmiavfggtlqvtqdkmiclpckwv
tkdscndsfrgwaasspeptypnstvlptpdtgptgikydldrhqynyvdavcyenrlhw
fakyfpylvllhtliflacsnfwfkfprtssklehfvsillkcfdspwttralsetvvee
sdpkpafskmngsmdkksstvsedveatvpmlqrtksrieqgivdrsetgvldkkegeqa
kalfekvkkfrthveegdivyrlymrqtiikvikfaliicytvyyvhnikfdvdctvdie
sltgyrtyrcahplatlfkilasfyislvifyglicmytlwwmlrrslkkysfesirees
sysdipdvkndfafmlhlidqydplyskrfavflsevsenklrqlnlnnewtldklrqrl
tknaqdklelhlfmlsgipdtvfdlvelevlklelipdvtippsiaqltglkelwlyhta
akieapalaflrenlralhikftdikeiplwiyslktleelhltgnlsaennryividgl
relkrlkvlrlksnlsklpqvvtdvgvhlqklsinnegtklivlnslkkmvnltelelir
cdleriphsifslhnlqeidlkdnnlktieeiisfqhlhrltclklwynhiayipiqign
ltnlerlylnrnkiekiptqlfycrklryldlshnnltflpadigllqnlqnlavtanri
ealppelfqcrklralhlgnnvlqslpsrvgeltnltqielrgnrleclpvelgecpllk
rsglvveedlfstlppevkerlwradkeqa

    Sequence, based on observed residues (ATOM records):
    >6g9oB (B:)
payrilkpwwdvftdyisivmlmiavfggtlqvtqdkmiclpckwvtkdscndstgptgi
kydldrhqynyvdavcyenrlhwfakyfpylvllhtliflacsnfwfkfprtssklehfv
sillkcfdspwttralsetgvldkkegeqakalfekvkkfrthveegdivyrlymrqtii
kvikfaliicytvyyvhnikfdvdctvdiesltgyrtyrcahplatlfkilasfyislvi
fyglicmytlwwmlrrslkkysfesireessysdipdvkndfafmlhlidqydplyskrf
avflsevsenklrqlnlnnewtldklrqrltknaqdklelhlfmlsgipdtvfdlvelev
lklelipdvtippsiaqltglkelwlyhtaakieapalaflrenlralhikftdikeipl
wiyslktleelhltgnlsaennryividglrelkrlkvlrlksnlsklpqvvtdvgvhlq
klsinnegtklivlnslkkmvnltelelircdleriphsifslhnlqeidlkdnnlktie
eiisfqhlhrltclklwynhiayipiqignltnlerlylnrnkiekiptqlfycrklryl
dlshnnltflpadigllqnlqnlavtanriealppelfqcrklralhlgnnvlqslpsrv
geltnltqielrgnrleclpvelgecpllkrsglvveedlfstlppevkerlwradke

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6g9oC (C:)
mipvtelryfadtqpayrilkpwwdvftdyisivmlmiavfggtlqvtqdkmiclpckwv
tkdscndsfrgwaasspeptypnstvlptpdtgptgikydldrhqynyvdavcyenrlhw
fakyfpylvllhtliflacsnfwfkfprtssklehfvsillkcfdspwttralsetvvee
sdpkpafskmngsmdkksstvsedveatvpmlqrtksrieqgivdrsetgvldkkegeqa
kalfekvkkfrthveegdivyrlymrqtiikvikfaliicytvyyvhnikfdvdctvdie
sltgyrtyrcahplatlfkilasfyislvifyglicmytlwwmlrrslkkysfesirees
sysdipdvkndfafmlhlidqydplyskrfavflsevsenklrqlnlnnewtldklrqrl
tknaqdklelhlfmlsgipdtvfdlvelevlklelipdvtippsiaqltglkelwlyhta
akieapalaflrenlralhikftdikeiplwiyslktleelhltgnlsaennryividgl
relkrlkvlrlksnlsklpqvvtdvgvhlqklsinnegtklivlnslkkmvnltelelir
cdleriphsifslhnlqeidlkdnnlktieeiisfqhlhrltclklwynhiayipiqign
ltnlerlylnrnkiekiptqlfycrklryldlshnnltflpadigllqnlqnlavtanri
ealppelfqcrklralhlgnnvlqslpsrvgeltnltqielrgnrleclpvelgecpllk
rsglvveedlfstlppevkerlwradkeqa

    Sequence, based on observed residues (ATOM records):
    >6g9oC (C:)
payrilkpwwdvftdyisivmlmiavfggtlqvtqdkmiclpckwvtkdscndstgptgi
kydldrhqynyvdavcyenrlhwfakyfpylvllhtliflacsnfwfkfprtssklehfv
sillkcfdspwttralsetgvldkkegeqakalfekvkkfrthveegdivyrlymrqtii
kvikfaliicytvyyvhnikfdvdctvdiesltgyrtyrcahplatlfkilasfyislvi
fyglicmytlwwmlrrslkkysfesireessysdipdvkndfafmlhlidqydplyskrf
avflsevsenklrqlnlnnewtldklrqrltknaqdklelhlfmlsgipdtvfdlvelev
lklelipdvtippsiaqltglkelwlyhtaakieapalaflrenlralhikftdikeipl
wiyslktleelhltgnlsaennryividglrelkrlkvlrlksnlsklpqvvtdvgvhlq
klsinnegtklivlnslkkmvnltelelircdleriphsifslhnlqeidlkdnnlktie
eiisfqhlhrltclklwynhiayipiqignltnlerlylnrnkiekiptqlfycrklryl
dlshnnltflpadigllqnlqnlavtanriealppelfqcrklralhlgnnvlqslpsrv
geltnltqielrgnrleclpvelgecpllkrsglvveedlfstlppevkerlwradke

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6g9oD (D:)
mipvtelryfadtqpayrilkpwwdvftdyisivmlmiavfggtlqvtqdkmiclpckwv
tkdscndsfrgwaasspeptypnstvlptpdtgptgikydldrhqynyvdavcyenrlhw
fakyfpylvllhtliflacsnfwfkfprtssklehfvsillkcfdspwttralsetvvee
sdpkpafskmngsmdkksstvsedveatvpmlqrtksrieqgivdrsetgvldkkegeqa
kalfekvkkfrthveegdivyrlymrqtiikvikfaliicytvyyvhnikfdvdctvdie
sltgyrtyrcahplatlfkilasfyislvifyglicmytlwwmlrrslkkysfesirees
sysdipdvkndfafmlhlidqydplyskrfavflsevsenklrqlnlnnewtldklrqrl
tknaqdklelhlfmlsgipdtvfdlvelevlklelipdvtippsiaqltglkelwlyhta
akieapalaflrenlralhikftdikeiplwiyslktleelhltgnlsaennryividgl
relkrlkvlrlksnlsklpqvvtdvgvhlqklsinnegtklivlnslkkmvnltelelir
cdleriphsifslhnlqeidlkdnnlktieeiisfqhlhrltclklwynhiayipiqign
ltnlerlylnrnkiekiptqlfycrklryldlshnnltflpadigllqnlqnlavtanri
ealppelfqcrklralhlgnnvlqslpsrvgeltnltqielrgnrleclpvelgecpllk
rsglvveedlfstlppevkerlwradkeqa

    Sequence, based on observed residues (ATOM records):
    >6g9oD (D:)
payrilkpwwdvftdyisivmlmiavfggtlqvtqdkmiclpckwvtkdscndstgptgi
kydldrhqynyvdavcyenrlhwfakyfpylvllhtliflacsnfwfkfprtssklehfv
sillkcfdspwttralsetgvldkkegeqakalfekvkkfrthveegdivyrlymrqtii
kvikfaliicytvyyvhnikfdvdctvdiesltgyrtyrcahplatlfkilasfyislvi
fyglicmytlwwmlrrslkkysfesireessysdipdvkndfafmlhlidqydplyskrf
avflsevsenklrqlnlnnewtldklrqrltknaqdklelhlfmlsgipdtvfdlvelev
lklelipdvtippsiaqltglkelwlyhtaakieapalaflrenlralhikftdikeipl
wiyslktleelhltgnlsaennryividglrelkrlkvlrlksnlsklpqvvtdvgvhlq
klsinnegtklivlnslkkmvnltelelircdleriphsifslhnlqeidlkdnnlktie
eiisfqhlhrltclklwynhiayipiqignltnlerlylnrnkiekiptqlfycrklryl
dlshnnltflpadigllqnlqnlavtanriealppelfqcrklralhlgnnvlqslpsrv
geltnltqielrgnrleclpvelgecpllkrsglvveedlfstlppevkerlwradke

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6g9oE (E:)
mipvtelryfadtqpayrilkpwwdvftdyisivmlmiavfggtlqvtqdkmiclpckwv
tkdscndsfrgwaasspeptypnstvlptpdtgptgikydldrhqynyvdavcyenrlhw
fakyfpylvllhtliflacsnfwfkfprtssklehfvsillkcfdspwttralsetvvee
sdpkpafskmngsmdkksstvsedveatvpmlqrtksrieqgivdrsetgvldkkegeqa
kalfekvkkfrthveegdivyrlymrqtiikvikfaliicytvyyvhnikfdvdctvdie
sltgyrtyrcahplatlfkilasfyislvifyglicmytlwwmlrrslkkysfesirees
sysdipdvkndfafmlhlidqydplyskrfavflsevsenklrqlnlnnewtldklrqrl
tknaqdklelhlfmlsgipdtvfdlvelevlklelipdvtippsiaqltglkelwlyhta
akieapalaflrenlralhikftdikeiplwiyslktleelhltgnlsaennryividgl
relkrlkvlrlksnlsklpqvvtdvgvhlqklsinnegtklivlnslkkmvnltelelir
cdleriphsifslhnlqeidlkdnnlktieeiisfqhlhrltclklwynhiayipiqign
ltnlerlylnrnkiekiptqlfycrklryldlshnnltflpadigllqnlqnlavtanri
ealppelfqcrklralhlgnnvlqslpsrvgeltnltqielrgnrleclpvelgecpllk
rsglvveedlfstlppevkerlwradkeqa

    Sequence, based on observed residues (ATOM records):
    >6g9oE (E:)
payrilkpwwdvftdyisivmlmiavfggtlqvtqdkmiclpckwvtkdscndstgptgi
kydldrhqynyvdavcyenrlhwfakyfpylvllhtliflacsnfwfkfprtssklehfv
sillkcfdspwttralsetgvldkkegeqakalfekvkkfrthveegdivyrlymrqtii
kvikfaliicytvyyvhnikfdvdctvdiesltgyrtyrcahplatlfkilasfyislvi
fyglicmytlwwmlrrslkkysfesireessysdipdvkndfafmlhlidqydplyskrf
avflsevsenklrqlnlnnewtldklrqrltknaqdklelhlfmlsgipdtvfdlvelev
lklelipdvtippsiaqltglkelwlyhtaakieapalaflrenlralhikftdikeipl
wiyslktleelhltgnlsaennryividglrelkrlkvlrlksnlsklpqvvtdvgvhlq
klsinnegtklivlnslkkmvnltelelircdleriphsifslhnlqeidlkdnnlktie
eiisfqhlhrltclklwynhiayipiqignltnlerlylnrnkiekiptqlfycrklryl
dlshnnltflpadigllqnlqnlavtanriealppelfqcrklralhlgnnvlqslpsrv
geltnltqielrgnrleclpvelgecpllkrsglvveedlfstlppevkerlwradke

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6g9oF (F:)
mipvtelryfadtqpayrilkpwwdvftdyisivmlmiavfggtlqvtqdkmiclpckwv
tkdscndsfrgwaasspeptypnstvlptpdtgptgikydldrhqynyvdavcyenrlhw
fakyfpylvllhtliflacsnfwfkfprtssklehfvsillkcfdspwttralsetvvee
sdpkpafskmngsmdkksstvsedveatvpmlqrtksrieqgivdrsetgvldkkegeqa
kalfekvkkfrthveegdivyrlymrqtiikvikfaliicytvyyvhnikfdvdctvdie
sltgyrtyrcahplatlfkilasfyislvifyglicmytlwwmlrrslkkysfesirees
sysdipdvkndfafmlhlidqydplyskrfavflsevsenklrqlnlnnewtldklrqrl
tknaqdklelhlfmlsgipdtvfdlvelevlklelipdvtippsiaqltglkelwlyhta
akieapalaflrenlralhikftdikeiplwiyslktleelhltgnlsaennryividgl
relkrlkvlrlksnlsklpqvvtdvgvhlqklsinnegtklivlnslkkmvnltelelir
cdleriphsifslhnlqeidlkdnnlktieeiisfqhlhrltclklwynhiayipiqign
ltnlerlylnrnkiekiptqlfycrklryldlshnnltflpadigllqnlqnlavtanri
ealppelfqcrklralhlgnnvlqslpsrvgeltnltqielrgnrleclpvelgecpllk
rsglvveedlfstlppevkerlwradkeqa

    Sequence, based on observed residues (ATOM records):
    >6g9oF (F:)
payrilkpwwdvftdyisivmlmiavfggtlqvtqdkmiclpckwvtkdscndstgptgi
kydldrhqynyvdavcyenrlhwfakyfpylvllhtliflacsnfwfkfprtssklehfv
sillkcfdspwttralsetgvldkkegeqakalfekvkkfrthveegdivyrlymrqtii
kvikfaliicytvyyvhnikfdvdctvdiesltgyrtyrcahplatlfkilasfyislvi
fyglicmytlwwmlrrslkkysfesireessysdipdvkndfafmlhlidqydplyskrf
avflsevsenklrqlnlnnewtldklrqrltknaqdklelhlfmlsgipdtvfdlvelev
lklelipdvtippsiaqltglkelwlyhtaakieapalaflrenlralhikftdikeipl
wiyslktleelhltgnlsaennryividglrelkrlkvlrlksnlsklpqvvtdvgvhlq
klsinnegtklivlnslkkmvnltelelircdleriphsifslhnlqeidlkdnnlktie
eiisfqhlhrltclklwynhiayipiqignltnlerlylnrnkiekiptqlfycrklryl
dlshnnltflpadigllqnlqnlavtanriealppelfqcrklralhlgnnvlqslpsrv
geltnltqielrgnrleclpvelgecpllkrsglvveedlfstlppevkerlwradke