PDB entry 6g7a

View 6g7a on RCSB PDB site
Description: Crystal structure of human carbonic anhydrase isozyme XII 2-(benzylamino)-4-chloro-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide
Class: lyase
Keywords: drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor comple, lyase
Deposited on 2018-04-05, released 2019-03-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-03-13, with a file datestamp of 2019-03-08.
Experiment type: XRAY
Resolution: 1.42 Å
R-factor: N/A
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CA12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6g7aa_
  • Chain 'B':
    Compound: Carbonic anhydrase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CA12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6g7ab_
  • Chain 'C':
    Compound: Carbonic anhydrase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CA12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6g7ac_
  • Chain 'D':
    Compound: Carbonic anhydrase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CA12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6g7ad_
  • Heterogens: ZN, EDO, EOQ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6g7aA (A:)
    mskwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfl
    ltnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivh
    ynsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfnie
    ellpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspr
    eminnfrqvqkfderlvytsfsq
    

    Sequence, based on observed residues (ATOM records): (download)
    >6g7aA (A:)
    skwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfll
    tnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivhy
    nsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfniee
    llpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspre
    minnfrqvqkfderlvytsfsq
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6g7aB (B:)
    mskwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfl
    ltnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivh
    ynsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfnie
    ellpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspr
    eminnfrqvqkfderlvytsfsq
    

    Sequence, based on observed residues (ATOM records): (download)
    >6g7aB (B:)
    skwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfll
    tnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivhy
    nsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfniee
    llpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspre
    minnfrqvqkfderlvytsfsq
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6g7aC (C:)
    mskwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfl
    ltnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivh
    ynsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfnie
    ellpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspr
    eminnfrqvqkfderlvytsfsq
    

    Sequence, based on observed residues (ATOM records): (download)
    >6g7aC (C:)
    skwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfll
    tnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivhy
    nsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfniee
    llpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspre
    minnfrqvqkfderlvytsfsq
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >6g7aD (D:)
    mskwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfl
    ltnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivh
    ynsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfnie
    ellpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspr
    eminnfrqvqkfderlvytsfsq
    

    Sequence, based on observed residues (ATOM records): (download)
    >6g7aD (D:)
    kwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfllt
    nnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivhyn
    sdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfnieel
    lpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpsprem
    innfrqvqkfderlvytsfsq