PDB entry 6g5x

View 6g5x on RCSB PDB site
Description: Crystal Structure of KDM4A with compound YP-02-145
Class: oxidoreductase
Keywords: KDM4A, ligand binding, drug design, inhibitor design, cancer, epigenetics, OXIDOREDUCTASE
Deposited on 2018-03-30, released 2019-04-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-10, with a file datestamp of 2019-04-05.
Experiment type: XRAY
Resolution: 1.78 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6g5xa_
  • Chain 'B':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6g5xb_
  • Heterogens: ZN, NI, EDO, CIT, GOL, MY7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6g5xA (A:)
    masesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyd
    diddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerk
    ywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgm
    wktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrh
    kmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieyg
    kqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel
    

    Sequence, based on observed residues (ATOM records): (download)
    >6g5xA (A:)
    sesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddi
    ddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkyw
    knltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwk
    tsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkm
    tlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkq
    avlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaef
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6g5xB (B:)
    masesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyd
    diddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerk
    ywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgm
    wktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrh
    kmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieyg
    kqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel
    

    Sequence, based on observed residues (ATOM records): (download)
    >6g5xB (B:)
    sarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddiddlvipap
    iqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywknltfnpp
    iygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwktsfawhte
    dmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplml
    kkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscrk
    dmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl