PDB entry 6g5w

View 6g5w on RCSB PDB site
Description: Crystal Structure of KDM4A with compound YP-03-038
Class: oxidoreductase
Keywords: KDM4A, ligand binding, drug design, inhibitor design, cancer, epigenetics, JMJD2A, oxidoreductase
Deposited on 2018-03-30, released 2019-04-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-10, with a file datestamp of 2019-04-05.
Experiment type: XRAY
Resolution: 1.83 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6g5wa_
  • Chain 'B':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6g5wb_
  • Heterogens: ZN, NI, EDO, CIT, NA, ENZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6g5wA (A:)
masesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyd
diddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerk
ywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgm
wktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrh
kmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieyg
kqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel

    Sequence, based on observed residues (ATOM records): (download) 
    >6g5wA (A:)
esetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddid
dlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywk
nltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwkt
sfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmt
lisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqa
vlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaae

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6g5wB (B:)
masesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyd
diddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerk
ywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgm
wktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrh
kmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieyg
kqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel

    Sequence, based on observed residues (ATOM records): (download) 
    >6g5wB (B:)
sarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddiddlvipap
iqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywknltfnpp
iygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwktsfawhte
dmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplml
kkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscrk
dmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaef