SCOPe 2.08: Structural Classification of Proteins

PDB entry 6g5g

View 6g5g on RCSB PDB site
Description: crystal structure of an engineered botulinum neurotoxin type b mutant e1191m/s1199y in complex with human synaptotagmin 2
Deposited on 2018-03-29, released 2019-01-16
The last revision was dated 2021-08-11, with a file datestamp of 2021-08-06.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: botulinum neurotoxin type b
Species: Clostridium botulinum [TaxId:1491]
Gene: botB
Database cross-references and differences (RAF-indexed):
- Uniprot P10844 (0-1290)
  - engineered mutation (230)
  - engineered mutation (233)
  - conflict (1190)
  - conflict (1198)
Chain 'B':
Compound: botulinum neurotoxin type b
Species: Clostridium botulinum [TaxId:1491]
Gene: botB
Database cross-references and differences (RAF-indexed):
- Uniprot P10844 (0-1290)
  - engineered mutation (230)
  - engineered mutation (233)
  - conflict (1190)
  - conflict (1198)
Chain 'P':
Compound: Synaptotagmin-2
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N9I0 (0-20)
Heterogens: MG, EDO, PEG, TRS, ACT, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

Chain 'A':
Sequence, based on SEQRES records:

>6g5gA (A:)
mpvtinnfnyndpidnnniimmeppfargtgryykafkitdriwiiperytfgykpedfn
kssgifnrdvceyydpdylntndkkniflqtmiklfnrikskplgekllemiingipylg
drrvpleefntniasvtvnklisnpgeverkkgifanliifgpgpvlnenetidigiqnh
fasregfggimqmkfcpeyvsvfnnvqenkgasifnrrgyfsdpalilmhqliyvlhgly
gikvddlpivpnekkffmqstdaiqaeelytfggqdpsiitpstdksiydkvlqnfrgiv
drlnkvlvcisdpnininiyknkfkdkykfvedsegkysidvesfdklykslmfgftetn
iaenykiktrasyfsdslppvkiknlldneiytieegfnisdkdmekeyrgqnkainkqa
yeeiskehlavykiqmcksvkapgicidvdnedlffiadknsfsddlsknerieyntqsn
yiendfpinelildtdliskielpsentesltdfnvdvpvyekqpaikkiftdentifqy
lysqtfpldirdisltssfddallfsnkvysffsmdyiktankvveaglfagwvkqivnd
fvieanksntmdkiadislivpyiglalnvgnetakgnfenafeiagasillefipelli
pvvgafllesyidnknkiiktidnaltkrnekwsdmyglivaqwlstvntqfytikegmy
kalnyqaqaleeiikyryniysekeksninidfndinsklneginqaidninnfingcsv
sylmkkmiplaveklldfdntlkknllnyidenklyligsaeyekskvnkylktimpfdl
siytndtiliemfnkynseilnniilnlrykdnnlidlsgygakvevydgvelndknqfk
ltssanskirvtqnqniifnsvfldfsvsfwiripkykndgiqnyihneytiincmknns
gwkisirgnriiwtlidingktksvffeynirediseyinrwffvtitnnlnnakiying
klesntdikdireviangeiifkldgdidrtqfiwmkyfsifntelsqsnieerykiqsy
seylkdfwgnplmynkeyymfnagnknsyiklkkdspvgeiltrskynqnskyinyrdly
igekfiirrksnsqsinddivrkedyiyldffnlnqewrvytykyfkkeemklflapiyd
sdefyntiqikeydeqptyscqllfkkdeestdeigligihrfyesgivfeeykdyfcis
kwylkevkrkpynlklgcnwqfipkdegwte

Sequence, based on observed residues (ATOM records):

>6g5gA (A:)
pvtinnfnyndpidnnniimmeppfargtgryykafkitdriwiiperytfgykpedfnk
ssgifnrdvceyydpdylntndkkniflqtmiklfnrikskplgekllemiingipylgd
rrvpleefntniasvtvnklisnpgeverkkgifanliifgpgpvlnenetidigiqnhf
asregfggimqmkfcpeyvsvfnnrgyfsdpalilmhqliyvlhglygikvddlpivpne
kkffmqstdaiqaeelytfggqdpsiitpstdksiydkvlqnfrgivdrlnkvlvcisdp
nininiyknkfkdkykfvedsegkysidvesfdklykslmfgftetniaenykiktrasy
fsdslppvkiknlldneiytieegfnisdkdmekeyrgqnkainkqayeeiskehlavyk
iqmcks

Chain 'B':
Sequence, based on SEQRES records:

>6g5gB (B:)
mpvtinnfnyndpidnnniimmeppfargtgryykafkitdriwiiperytfgykpedfn
kssgifnrdvceyydpdylntndkkniflqtmiklfnrikskplgekllemiingipylg
drrvpleefntniasvtvnklisnpgeverkkgifanliifgpgpvlnenetidigiqnh
fasregfggimqmkfcpeyvsvfnnvqenkgasifnrrgyfsdpalilmhqliyvlhgly
gikvddlpivpnekkffmqstdaiqaeelytfggqdpsiitpstdksiydkvlqnfrgiv
drlnkvlvcisdpnininiyknkfkdkykfvedsegkysidvesfdklykslmfgftetn
iaenykiktrasyfsdslppvkiknlldneiytieegfnisdkdmekeyrgqnkainkqa
yeeiskehlavykiqmcksvkapgicidvdnedlffiadknsfsddlsknerieyntqsn
yiendfpinelildtdliskielpsentesltdfnvdvpvyekqpaikkiftdentifqy
lysqtfpldirdisltssfddallfsnkvysffsmdyiktankvveaglfagwvkqivnd
fvieanksntmdkiadislivpyiglalnvgnetakgnfenafeiagasillefipelli
pvvgafllesyidnknkiiktidnaltkrnekwsdmyglivaqwlstvntqfytikegmy
kalnyqaqaleeiikyryniysekeksninidfndinsklneginqaidninnfingcsv
sylmkkmiplaveklldfdntlkknllnyidenklyligsaeyekskvnkylktimpfdl
siytndtiliemfnkynseilnniilnlrykdnnlidlsgygakvevydgvelndknqfk
ltssanskirvtqnqniifnsvfldfsvsfwiripkykndgiqnyihneytiincmknns
gwkisirgnriiwtlidingktksvffeynirediseyinrwffvtitnnlnnakiying
klesntdikdireviangeiifkldgdidrtqfiwmkyfsifntelsqsnieerykiqsy
seylkdfwgnplmynkeyymfnagnknsyiklkkdspvgeiltrskynqnskyinyrdly
igekfiirrksnsqsinddivrkedyiyldffnlnqewrvytykyfkkeemklflapiyd
sdefyntiqikeydeqptyscqllfkkdeestdeigligihrfyesgivfeeykdyfcis
kwylkevkrkpynlklgcnwqfipkdegwte

Sequence, based on observed residues (ATOM records):

>6g5gB (B:)
gicidvdnedlffiadknsfsddlsknerieyntqsnyiendfpinelildtdliskiel
psentesltdfnvdvpvyekqpaikkiftdentifqylysqtfpldirdisltssfddal
lfsnkvysffsmdyiktankvveaglfagwvkqivndfvieanksntmdkiadislivpy
iglalnvgnetakgnfenafeiagasillefipellipvvgafllesyidnknkiiktid
naltkrnekwsdmyglivaqwlstvntqfytikegmykalnyqaqaleeiikyryniyse
keksninidfndinsklneginqaidninnfingcsvsylmkkmiplaveklldfdntlk
knllnyidenklyligsaeyekskvnkylktimpfdlsiytndtiliemfnkynseilnn
iilnlrykdnnlidlsgygakvevydgvelndknqfkltssanskirvtqnqniifnsvf
ldfsvsfwiripkykndgiqnyihneytiincmknnsgwkisirgnriiwtlidingktk
svffeynirediseyinrwffvtitnnlnnakiyingklesntdikdireviangeiifk
ldgdidrtqfiwmkyfsifntelsqsnieerykiqsyseylkdfwgnplmynkeyymfna
gnknsyiklkkdspvgeiltrskynqnskyinyrdlyigekfiirrksnsqsinddivrk
edyiyldffnlnqewrvytykyfkkeemklflapiydsdefyntiqikeydeqptyscql
lfkkdeestdeigligihrfyesgivfeeykdyfciskwylkevkrkpynlklgcnwqfi
pkdegwte

Chain 'P':
Sequence, based on SEQRES records:
```
>6g5gP (P:)
gesqedmfaklkeklfneink
```
Sequence, based on observed residues (ATOM records):
```
>6g5gP (P:)
qedmfaklkeklfneink
```