PDB entry 6g4l

View 6g4l on RCSB PDB site
Description: 17beta-hydroxysteroid dehydrogenase type 14 mutant y253a in complex with a non-steroidal inhibitor
Deposited on 2018-03-27, released 2019-04-10
The last revision was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 1.44 Å
R-factor: N/A
AEROSPACI score: 0.59 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 17-beta-hydroxysteroid dehydrogenase 14
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD17B14, DHRS10, SDR3, SDR47C1, UNQ502/PRO474
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BPX1
      • conflict (204)
      • engineered mutation (252)
  • Heterogens: NAD, NA, BGC, F45, DMS, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6g4lA (A:)
matgtryagkvvvvtgggrgigagivrafvnsgarvvicdkdesggraleqelpgavfil
cdvtqeddvktlvsetirrfgrldcvvnnaghhpppqrpeetsaqgfrqllelnllgtyt
ltklalpylrksqgnvinisslvgaigqaqavpyvatkgavtamtkalaldespygvrvn
cispgniwtplweelaalmpdprasiregmlaqplgrmgqpaevgaaavflaseanfctg
iellvtggaelgagckasrstpvdapdips

    Sequence, based on observed residues (ATOM records):
    >6g4lA (A:)
tryagkvvvvtgggrgigagivrafvnsgarvvicdkdesggraleqelpgavfilcdvt
qeddvktlvsetirrfgrldcvvnnaghhpppqrpeetsaqgfrqllelnllgtytltkl
alpylrksqgnvinisslvgaigqaqavpyvatkgavtamtkalaldespygvrvncisp
gniwtplweelaalmpdprasiregmlaqplgrmgqpaevgaaavflaseanfctgiell
vtggaelgagpdi