PDB entry 6g33

View 6g33 on RCSB PDB site
Description: Crystal structure of CLK1 in complex with 5-iodotubercidin
Class: transferase
Keywords: kinase, inhibitors, slow off-rate, kinetics, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Deposited on 2018-03-24, released 2018-04-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-06-13, with a file datestamp of 2018-06-08.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity protein kinase CLK1
    Species: Homo sapiens [TaxId:9606]
    Gene: CLK1, CLK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49759 (2-End)
      • expression tag (0-1)
      • variant (286)
    Domains in SCOPe 2.08: d6g33a1, d6g33a2
  • Chain 'B':
    Compound: Dual specificity protein kinase CLK1
    Species: Homo sapiens [TaxId:9606]
    Gene: CLK1, CLK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49759 (2-End)
      • expression tag (0-1)
      • variant (286)
    Domains in SCOPe 2.08: d6g33b1, d6g33b2
  • Chain 'C':
    Compound: Dual specificity protein kinase CLK1
    Species: Homo sapiens [TaxId:9606]
    Gene: CLK1, CLK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49759 (2-End)
      • expression tag (0-1)
      • variant (286)
    Domains in SCOPe 2.08: d6g33c1, d6g33c2
  • Heterogens: 5ID, IOD, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6g33A (A:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkksi

    Sequence, based on observed residues (ATOM records): (download) 
    >6g33A (A:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6g33B (B:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkksi

    Sequence, based on observed residues (ATOM records): (download) 
    >6g33B (B:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6g33C (C:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkksi

    Sequence, based on observed residues (ATOM records): (download) 
    >6g33C (C:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkk