PDB entry 6fyh

View 6fyh on RCSB PDB site
Description: Disulfide between ubiquitin G76C and the E3 HECT ligase Huwe1
Class: ligase
Keywords: HUWE1 HECT, Ubiquitin transfer, thioester, LIGASE
Deposited on 2018-03-12, released 2018-07-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-03-06, with a file datestamp of 2019-03-01.
Experiment type: XRAY
Resolution: 2.91 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase HUWE1
    Species: Homo sapiens [TaxId:9606]
    Gene: HUWE1, KIAA0312, KIAA1578, UREB1, HSPC272
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7Z6Z7 (4-End)
      • engineered mutation (116)
  • Chain 'B':
    Compound: Polyubiquitin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: UBB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0CG47 (0-75)
      • engineered mutation (75)
    Domains in SCOPe 2.08: d6fyhb_
  • Heterogens: SO4, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fyhB (B:)
mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
iqkestlhlvlrlrgc