PDB entry 6fx4

View 6fx4 on RCSB PDB site
Description: Disulfide between E3 HECT ligase Smurf2 and Ubiquitin G76C
Class: ligase
Keywords: E3 HECT ligase, Ubiquitin transfer, LIGASE
Deposited on 2018-03-08, released 2018-07-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-03-06, with a file datestamp of 2019-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase SMURF2
    Species: Homo sapiens [TaxId:9606]
    Gene: SMURF2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HAU4 (4-End)
      • expression tag (1-3)
      • engineered mutation (19)
      • engineered mutation (79)
      • engineered mutation (116)
  • Chain 'B':
    Compound: Polyubiquitin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: UBB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0CG47 (0-75)
      • engineered mutation (75)
    Domains in SCOPe 2.08: d6fx4b_
  • Chain 'C':
    Compound: E3 ubiquitin-protein ligase SMURF2
    Species: Homo sapiens [TaxId:9606]
    Gene: SMURF2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HAU4 (4-118)
      • expression tag (2-3)
      • engineered mutation (19)
      • engineered mutation (79)
      • engineered mutation (116)
  • Chain 'D':
    Compound: Polyubiquitin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: UBB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0CG47 (0-75)
      • engineered mutation (75)
    Domains in SCOPe 2.08: d6fx4d_
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fx4B (B:)
mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
iqkestlhlvlrlrgc

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fx4D (D:)
mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
iqkestlhlvlrlrgc