PDB entry 6fx0

View 6fx0 on RCSB PDB site
Description: structure-based design of trifarotene (cd5789), a potent and selective rar gamma agonist for the treatment of acne
Deposited on 2018-03-08, released 2018-05-23
The last revision was dated 2018-05-23, with a file datestamp of 2018-05-18.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: retinoic acid receptor gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: RARG, NR1B3
    Database cross-references and differences (RAF-indexed):
  • Heterogens: E9T, PG4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6fx0A (A:)
matnkerlfaagalgpgsgypgagfpfafpgalrgsppfemlspsfrglgqpdlpkemas
lsvetqstsseemvpsspsppppprvykpcfvcndkssgyhygvsscegckgffrrsiqk
nmvytchrdknciinkvtrnrcqycrlqkcfevgmskeavrndrnkkkkevkeegspdsy
elspqleelitkvskahqetfpslcqlgkyttnssadhrvqldlglwdkfselatkciik
ivefakrlpgftglsiadqitllkaacldilmlrictrytpeqdtmtfsdgltlnrtqmh
nagfgpltdlvfafagqllplemddtetgllsaiclicgdrmdleepekvdklqepllea
lrlyarrrrpsqpymfprmlmkitdlrgistkgaeraitlkmeipgpmppliremlenpe
mfeddssqpgphpnassedevpggqgkgglkspa

    Sequence, based on observed residues (ATOM records):
    >6fx0A (A:)
yelspqleelitkvskahqetfpslcqlgkyttnssadhrvqldlglwdkfselatkcii
kivefakrlpgftglsiadqitllkaacldilmlrictrytpeqdtmtfsdgltlnrtqm
hnagfgpltdlvfafagqllplemddtetgllsaiclicgdrmdleepekvdklqeplle
alrlyarrrrpsqpymfprmlmkitdlrgistkgaeraitlkmeipgpmppliremle