PDB entry 6fwk

View 6fwk on RCSB PDB site
Description: the crystal structure of pol2core-m644g in complex with dna and an incoming nucleotide
Deposited on 2018-03-06, released 2019-01-30
The last revision was dated 2019-02-06, with a file datestamp of 2019-02-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA polymerase epsilon catalytic subunit A
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: POL2, DUN2, YNL262W, N0825
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21951
      • engineered mutation (648)
  • Chain 'B':
    Compound: DNA polymerase epsilon catalytic subunit A
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: POL2, DUN2, YNL262W, N0825
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21951
      • engineered mutation (648)
  • Chain 'C':
    Compound: DNA (5'-d(p*tp*ap*ap*cp*cp*gp*cp*gp*tp*tp*(doc))-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'D':
    Compound: DNA (5'-d(p*tp*cp*tp*tp*gp*ap*ap*cp*gp*cp*gp*gp*tp*tp*a)-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'P':
    Compound: DNA (5'-d(p*tp*ap*ap*cp*cp*gp*cp*gp*tp*tp*(doc))-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'T':
    Compound: DNA (5'-d(p*tp*cp*tp*tp*gp*ap*ap*cp*gp*cp*gp*gp*tp*tp*a)-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Heterogens: DTP, CA, FE, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6fwkA (A:)
ggdphmmfgkkknnggsstarysagnkyntlsnnyalsaqqllnaskiddidsmmgfery
vppqyngrfdakdidqipgrvgwltnmhatlvsqetlssgsngggnsndgervttnqgis
gvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqiirkedl
tmdnhllglqktliklsfvnsnqlfearkllrpilqdnannnvqrniynvaangsekvda
khliedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafdiettk
pplkfpdsavdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnende
vallqrffehirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykss
ycshmdcfrwvkrdsylpqgsqglkavtqsklgynpieldpelmtpyafekpqhlseysv
sdavatyylymkyvhpfifslctiiplnpdetlrkgtgtlcemllmvqayqhnillpnkh
tdpierfydghllesetyvgghvesleagvfrsdlknefkidpsaidellqelpealkfs
vevenkssvdkvtnfeeiknqitqkllelkennirnelpliyhvdvasgypnimttnrlq
pdsikaerdcascdfnrpgktcarklkwawrgeffpskmdeynmikralqnetfpnknkf
skkkvltfdelsyadqvihikkrlteysrkvyhrvkvseivereaivcqrenpfyvdtvk
sfrdrryefkglaktwkgnlskidpsdkhardeakkmivlydslqlahkvilnsfygyvm
rkgsrwysmemagitcltgatiiqmaralvervgrpleldtdgiwcilpksfpetyfftl
engkklylsypcsmlnyrvhqkftnhqyqelkdplnyiyethsentiffevdgpykamil
psskeegkgikkryavfnedgslaelkgfelkrrgelqliknfqsdifkvflegdtlegc
ysavasvcnrwldvldshglmlededlvslicenrsmsktlkeyegqkstsittarrlgd
flgedmvkdkglqckyiisskpfnapvteraipvaifsadipikrsflrrwtldpsledl
dirtiidwgyyrerlgsaiqkiitipaalqgvsnpvprvehpdwlkrkiat

    Sequence, based on observed residues (ATOM records):
    >6fwkA (A:)
alsaqqllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvsqe
qgisgvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqiir
kedltmdnhllglqktliklsfvnsnqlfearkllrpilqdnannnvqrniynkvdakhl
iedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafdiettkppl
kfpdsavdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnendeval
lqrffehirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykssycs
hmdcfrwvkrdsylpqgsqglkavtqsklgynpieldpelmtpyafekpqhlseysvsda
vatyylymkyvhpfifslctiiplnpdetlrkgtgtlcemllmvqayqhnillpnkhtdp
ierfydghllesetyvgghvesleagvfrsdlknefkidpsaidellqelpealkfsvev
enkssvdkvtnfeeiknqitqkllelkennirnelpliyhvdvasgypnimttnrlqpds
iktcarklkwawrgeffpskmdeynmikralqnetfpvltfdelsyadqvihikkrltey
srkvyhrvkvseivereaivcqrenpfyvdtvksfrdrryefkglaktwkgnlskidpsd
khardeakkmivlydslqlahkvilnsfygyvmrkgsrwysmemagitcltgatiiqmar
alvervgrpleldtdgiwcilpksfpetyfftlengkklylsypcsmlnyrvhqkftnhq
yqelkdplnyiyethsentiffevdgpykamilpsskeegkgikkryavfnedgslaelk
gfelkrrgelqliknfqsdifkvflegdtlegcysavasvcnrwldvldshglmlededl
vslicenrsmsktlkeyegqkstsittarrlgdflgedmvkdkglqckyiisskpfnapv
teraipvaifsadipikrsflrrwtldpsledldirtiidwgyyrerlgsaiqkiitipa
alqgvsnpvprvehpdwlkrkia

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6fwkB (B:)
ggdphmmfgkkknnggsstarysagnkyntlsnnyalsaqqllnaskiddidsmmgfery
vppqyngrfdakdidqipgrvgwltnmhatlvsqetlssgsngggnsndgervttnqgis
gvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqiirkedl
tmdnhllglqktliklsfvnsnqlfearkllrpilqdnannnvqrniynvaangsekvda
khliedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafdiettk
pplkfpdsavdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnende
vallqrffehirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykss
ycshmdcfrwvkrdsylpqgsqglkavtqsklgynpieldpelmtpyafekpqhlseysv
sdavatyylymkyvhpfifslctiiplnpdetlrkgtgtlcemllmvqayqhnillpnkh
tdpierfydghllesetyvgghvesleagvfrsdlknefkidpsaidellqelpealkfs
vevenkssvdkvtnfeeiknqitqkllelkennirnelpliyhvdvasgypnimttnrlq
pdsikaerdcascdfnrpgktcarklkwawrgeffpskmdeynmikralqnetfpnknkf
skkkvltfdelsyadqvihikkrlteysrkvyhrvkvseivereaivcqrenpfyvdtvk
sfrdrryefkglaktwkgnlskidpsdkhardeakkmivlydslqlahkvilnsfygyvm
rkgsrwysmemagitcltgatiiqmaralvervgrpleldtdgiwcilpksfpetyfftl
engkklylsypcsmlnyrvhqkftnhqyqelkdplnyiyethsentiffevdgpykamil
psskeegkgikkryavfnedgslaelkgfelkrrgelqliknfqsdifkvflegdtlegc
ysavasvcnrwldvldshglmlededlvslicenrsmsktlkeyegqkstsittarrlgd
flgedmvkdkglqckyiisskpfnapvteraipvaifsadipikrsflrrwtldpsledl
dirtiidwgyyrerlgsaiqkiitipaalqgvsnpvprvehpdwlkrkiat

    Sequence, based on observed residues (ATOM records):
    >6fwkB (B:)
yalsaqqllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvsq
enqgisgvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqi
irkedltmdnhllglqktliklsfvnsnqlfearkllrpilqdnannnvqrniynvvdak
hliedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafdiettkp
plkfpdsavdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnendev
allqrffehirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykssy
cshmdcfrwvkrdsylpqgsqglkavtqsklgynpieldpelmtpyafekpqhlseysvs
davatyylymkyvhpfifslctiiplnpdetlrkgtgtlcemllmvqayqhnillpnkht
dpierfydghllesetyvgghvesleagvfrsdlknefkidpsaidellqelpealkfsv
evenkssvdkvtnfeeiknqitqkllelkennirnelpliyhvdvasgypnimttnrlqp
dsiktcarklkwawrgeffpskmdeynmikralqnetfpnltfdelsyadqvihikkrlt
eysrkvseivereaivcqrenpfyvdtvksfrdrryefkglaktwkgnlskidpsdkhar
deakkmivlydslqlahkvilnsfygyvmrkgsrwysmemagitcltgatiiqmaralve
rvgrpleldtdgiwcilpksfpetyfftlengkklylsypcsmlnyrvhqkftnhqyqel
kdplnyiyethsentiffevdgpykamilpsskeegkgikkryavfnedgslaelkgfel
krrgelqliknfqsdifkvflegdtlegcysavasvcnrwldvldshglmlededlvsli
cenrsmsktlkeyegqkstsittarrlgdflgedmvkdkglqckyiisskpfnapvtera
ipvaifsadipikrsflrrwtldpsledldirtiidwgyyrerlgsaiqkiitipaalqg
vsnpvprvehpdwlkrkia

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'P':
    No sequence available.

  • Chain 'T':
    No sequence available.