PDB entry 6fwd

View 6fwd on RCSB PDB site
Description: Crystal structure of human transthyretin double mutant R34G/T119M at pH 5.5
Class: transport protein
Keywords: Amyloid, Gatekeeper, Aggregation, Stability, TRANSPORT PROTEIN
Deposited on 2018-03-06, released 2019-03-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-03-20, with a file datestamp of 2019-03-15.
Experiment type: XRAY
Resolution: 1.58 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: TTR, PALB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766
      • engineered mutation (33)
      • engineered mutation (118)
    Domains in SCOPe 2.08: d6fwda_
  • Chain 'B':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: TTR, PALB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766
      • engineered mutation (33)
      • engineered mutation (118)
    Domains in SCOPe 2.08: d6fwdb_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6fwdA (A:)
gptgtgeskcplmvkvldavrgspainvavhvfgkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispfhehaevvftandsgprrytiaallspysystma
vvtnpke

    Sequence, based on observed residues (ATOM records): (download) 
    >6fwdA (A:)
cplmvkvldavrgspainvavhvfgkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysystmavvtnp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6fwdB (B:)
gptgtgeskcplmvkvldavrgspainvavhvfgkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispfhehaevvftandsgprrytiaallspysystma
vvtnpke

    Sequence, based on observed residues (ATOM records): (download) 
    >6fwdB (B:)
cplmvkvldavrgspainvavhvfgkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsrrytiaallspysystmavvtnp