PDB entry 6fuw

View 6fuw on RCSB PDB site
Description: cryo-em structure of the human cpsf160-wdr33-cpsf30 complex bound to the pas aauaaa motif at 3.1 angstrom resolution
Deposited on 2018-02-28, released 2018-03-21
The last revision was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: EM
Resolution: 3.07 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cleavage and polyadenylation specificity factor subunit 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF1, CPSF160
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q10570 (3-1445)
      • expression tag (1-2)
  • Chain 'B':
    Compound: pre-mRNA 3' end processing protein WDR33
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR33, WDC146
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Cleavage and polyadenylation specificity factor subunit 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF4, CPSF30, NAR, NEB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: RNA (5'-r(p*ap*ap*up*ap*ap*ap*gp*g)-3')
    Species: unidentified adenovirus, synthetic [TaxId:10535]
  • Heterogens: ZN

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6fuwA (A:)
snamyavykqahpptglefsmycnffnnsernlvvagtsqlyvyrlnrdaealtkndrst
egkahreklelaasfsffgnvmsmasvqlagakrdalllsfkdaklsvveydpgthdlkt
lslhyfeepelrdgfvqnvhtprvrvdpdgrcaamlvygtrlvvlpfrreslaeeheglv
gegqrssflpsyiidvraldekllniidlqflhgyyeptllilfepnqtwpgrvavrqdt
csivaislnitqkvhpviwsltslpfdctqalavpkpiggvvvfavnsllylnqsvppyg
valnslttgttafplrtqegvritldcaqatfisydkmvislkggeiyvltlitdgmrsv
rafhfdkaaasvlttsmvtmepgylflgsrlgnslllkyteklqeppasavreaadkeep
pskkkrvdatagwsaagksvpqdevdeievygseaqsgtqlatysfevcdsilnigpcan
aavgepaflseefqnspepdleivvcsghgkngalsvlqksirpqvvttfelpgcydmwt
viapvrkeeednpkgegteqepsttpeadddgrrhgflilsredstmilqtgqeimeldt
sgfatqgptvfagnigdnryivqvsplgirllegvnqlhfipvdlgapivqcavadpyvv
imsaeghvtmfllksdsyggrhhrlalhkpplhhqskvitlclyrdlsgmfttesrlgga
rdelggrsgpeaeglgsetsptvddeeemlygdsgslfspskeearrssqppadrdpapf
raepthwcllvrengtmeiyqlpdwrlvflvknfpvgqrvlvdssfgqpttqgearreea
trqgelplvkevllvalgsrqsrpyllvhvdqelliyeafphdsqlgqgnlkvrfkkvph
ninfrekkpkpskkkaegggaeegagargrvarfryfediygysgvficgpsphwllvtg
rgalrlhpmaidgpvdsfapfhnvncprgflyfnrqgelrisvlpaylsydapwpvrkip
lrctahyvayhveskvyavatstntpcariprmtgeekefetierderyihpqqeafsiq
lispvsweaipnarielqewehvtcmktvslrseetvsglkgyvaagtclmqgeevtcrg
rilimdvievvpepgqpltknkfkvlyekeqkgpvtalchcnghlvsaigqkiflwslra
seltgmafidtqlyihqmisvknfilaadvmksisllryqeesktlslvsrdakplevys
vdfmvdnaqlgflvsdrdrnlmvymylpeakesfggmrllrradfhvgahvntfwrtpcr
gateglskksvvwenkhitwfatldggiglllpmqektyrrllmlqnalttmlphhagln
prafrmlhvdrrtlqnavrnvldgellnrylylstmerselakkigttpdiilddlletd
rvtahf

    Sequence, based on observed residues (ATOM records):
    >6fuwA (A:)
namyavykqahpptglefsmycnffnnsernlvvagtsqlyvyrlnrdareklelaasfs
ffgnvmsmasvqlagakrdalllsfkdaklsvveydpgthdlktlslhyfeepelrdgfv
qnvhtprvrvdpdgrcaamlvygtrlvvlpfrrssflpsyiidvraldekllniidlqfl
hgyyeptllilfepnqtwpgrvavrqdtcsivaislnitqkvhpviwsltslpfdctqal
avpkpiggvvvfavnsllylnqsvppygvalnslttgttafplrtqegvritldcaqatf
isydkmvislkggeiyvltlitdgmrsvrafhfdkaaasvlttsmvtmepgylflgsrlg
nslllkyteklatysfevcdsilnigpcanaavgepaflseefqnspepdleivvcsghg
kngalsvlqksirpqvvttfelpgcydmwtviapgrrhgflilsredstmilqtgqeime
ldtsgfatqgptvfagnigdnryivqvsplgirllegvnqlhfipvdlgapivqcavadp
yvvimsaeghvtmfllkshrlalhkpplhhqskvitlclyrdlsgmfttepthwcllvre
ngtmeiyqlpdwrlvflvknfpvgqrvlvdssplvkevllvalgsrqsrpyllvhvdqel
liyeafphdgqgnlkvrfkkvphninfrervarfryfediygysgvficgpsphwllvtg
rgalrlhpmaidgpvdsfapfhnvncprgflyfnrqgelrisvlpaylsydapwpvrkip
lrctahyvayhveskvyavatstntpcariprmekefetierderyihpqqeafsiqlis
pvsweaipnarielqewehvtcmktvslrseetvsglkgyvaagtclmqgeevtcrgril
imdvievvppltknkfkvlyekeqkgpvtalchcnghlvsaigqkiflwslraseltgma
fidtqlyihqmisvknfilaadvmksisllryqeesktlslvsrdakplevysvdfmvdn
aqlgflvsdrdrnlmvymylpeakesfggmrllrradfhvgahvntfwrtpcrvwenkhi
twfatldggiglllpmqektyrrllmlqnalttmlphhaglnprafrmlhnavrnvldge
llnrylylstmerselakkigttpdiilddlletdrvtahf

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6fuwB (B:)
snamateigspprffhmprfqhqaprqlfykrpdfaqqqamqqltfdgkrmrkavnrkti
dynpsvikylenriwqrdqrdmraiqpdagyyndlvppigmlnnpmnavttkfvrtstnk
vkcpvfvvrwtpegrrlvtgassgeftlwngltfnfetilqahdspvramtwshndmwml
tadhggyvkywqsnmnnvkmfqahkeaireasfsptdnkfatcsddgtvriwdflrchee
rilrghgadvkcvdwhptkglvvsgskdsqqpikfwdpktgqslatlhahkntvmevkln
lngnwlltasrdhlcklfdirnlkeelqvfrghkkeatavawhpvheglfasggsdgsll
fwhvgvekevggmemahegmiwslawhplghilcsgsndhtskfwtrnrpgdk

    Sequence, based on observed residues (ATOM records):
    >6fuwB (B:)
ltfdgkrmrkavnrktidynpsvikylenriwqrdqrdmraiqpdagyyndlvppigmln
npmnavttkfvrtstnkvkcpvfvvrwtpegrrlvtgassgeftlwngltfnfetilqah
dspvramtwshndmwmltadhggyvkywqsnmnnvkmfqahkeaireasfsptdnkfatc
sddgtvriwdflrcheerilrghgadvkcvdwhptkglvvsgskdsqqpikfwdpktgqs
latlhahkntvmevklnlngnwlltasrdhlcklfdirnlkeelqvfrghkkeatavawh
pvheglfasggsdgsllfwhvgvekevggmemahegmiwslawhplghilcsgsndhtsk
fwtrnrpgdk

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6fuwC (C:)
mqeiiasvdhikfdleiaveqqlgaqplpfpgmdksgaavcefflkaacgkggmcpfrhi
sgektvvckhwlrglckkgdqceflheydmtkmpecyfyskfgecsnkecpflhidpesk
ikdcpwydrgfckhgplcrhrhtrrvicvnylvgfcpegpsckfmhprfelpmgtteq

    Sequence, based on observed residues (ATOM records):
    >6fuwC (C:)
mqeiiasvdhikfdleiaveqqlgaqplpfpgmksgaavcefflkaacgkggmcpfrhis
gektvvckhwlrglckkgdqceflheydmtkmpecyfyskfgecsnkecpflhi

  • Chain 'D':
    No sequence available.