PDB entry 6ftp

View 6ftp on RCSB PDB site
Description: crystal form 1 of alpha1-antichymotrypsin variant dbs-ii-allo: an allosterically modulated drug-binding serpin for doxorubicin
Deposited on 2018-02-22, released 2018-05-23
The last revision was dated 2018-06-06, with a file datestamp of 2018-06-01.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: alpha-1-antichymotrypsin
    Species: Homo sapiens [TaxId:9606]
    Gene: SERPINA3, AACT, GIG24, GIG25
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01011 (Start-368)
      • engineered mutation (202)
      • engineered mutation (223)
      • engineered mutation (250)
      • engineered mutation (252)
      • engineered mutation (277-278)
      • engineered mutation (282)
      • engineered mutation (284-286)
      • engineered mutation (357)
      • engineered mutation (363-368)
  • Chain 'B':
    Compound: alpha-1-antichymotrypsin
    Species: Homo sapiens [TaxId:9606]
    Gene: SERPINA3, AACT, GIG24, GIG25
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01011 (Start-39)
      • engineered mutation (21-23)
      • engineered mutation (25-26)
  • Heterogens: EDO, DM2, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6ftpA (A:)
    mkhhhhhhmkqnspldeenltqenqdrgthvdrglasanvdfafslykqlvlkapdknvi
    fsplsistalaflslgahnttlteilkglkfnltetseaeihqsfqhllrtlnqssdelq
    lsmgnamfvkeqlslldrftedakrlygseafatdfqdsaaakklindyvkngtrgkitd
    likdldsqtmmvlvnyiffkakfempfdpqdthqsrfylskkkyvmvpmmslhhltipyf
    rdeelsctvvqlnytgnasalfilpdqdkmeeveamlsqetlsrffeslefreigelylp
    kfsisrdynlndillqlgieeaftskadlsgitgarnlavsqvvhkavldvfeegtersa
    atalevlfq
    

    Sequence, based on observed residues (ATOM records):
    >6ftpA (A:)
    lasanvdfafslykqlvlkapdknvifsplsistalaflslgahnttlteilkglkfnlt
    etseaeihqsfqhllrtlnqssdelqlsmgnamfvkeqlslldrftedakrlygseafat
    dfqdsaaakklindyvkngtrgkitdlikdldsqtmmvlvnyiffkakfempfdpqdthq
    srfylskkkyvmvpmmslhhltipyfrdeelsctvvqlnytgnasalfilpdqdkmeeve
    amlsqetlsrffeslefreigelylpkfsisrdynlndillqlgieeaftskadlsgitg
    arnlavsqvvhkavldvfeegtersaatalevlfq
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6ftpB (B:)
    gplvetrtivrfnrpflmiivdnftwsiffmskvtnpkqa
    

    Sequence, based on observed residues (ATOM records):
    >6ftpB (B:)
    rtivrfnrpflmiivdnftwsiffmskvtnpkqa