SCOPe 2.08: Structural Classification of Proteins

PDB entry 6ft9

View 6ft9 on RCSB PDB site
Description: Crystal structure of CLK1 in complex with inhibitor 16
Class: transferase
Keywords: kinase, inhibitor, splicing kinase, CLK, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Deposited on 2018-02-20, released 2018-05-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-05-16, with a file datestamp of 2018-05-11.
Experiment type: XRAY
Resolution: 1.87 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Dual specificity protein kinase CLK1
Species: Homo sapiens [TaxId:9606]
Gene: CLK1, CLK
Database cross-references and differences (RAF-indexed):
- Uniprot P49759 (2-End)
  - expression tag (1)
  - variant (286)
  - conflict (286)
Domains in SCOPe 2.08: d6ft9a1, d6ft9a2
Chain 'B':
Compound: Dual specificity protein kinase CLK1
Species: Homo sapiens [TaxId:9606]
Gene: CLK1, CLK
Database cross-references and differences (RAF-indexed):
- Uniprot P49759 (2-End)
  - expression tag (0-1)
  - variant (286)
  - conflict (286)
Domains in SCOPe 2.08: d6ft9b1, d6ft9b2
Chain 'C':
Compound: Dual specificity protein kinase CLK1
Species: Homo sapiens [TaxId:9606]
Gene: CLK1, CLK
Database cross-references and differences (RAF-indexed):
- Uniprot P49759 (2-End)
  - expression tag (0-1)
  - variant (286)
  - conflict (286)
Domains in SCOPe 2.08: d6ft9c1, d6ft9c2
Heterogens: E6W, BR, PO4, GOL, NA, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>6ft9A (A:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkksi

Sequence, based on observed residues (ATOM records): (download)

>6ft9A (A:)
mhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaarse
iqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhir
kmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvdf
gsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdske
hlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdve
herlfdliqkmleydpakritlrealkhpffdllkk

Chain 'B':
Sequence, based on SEQRES records: (download)

>6ft9B (B:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkksi

Sequence, based on observed residues (ATOM records): (download)

>6ft9B (B:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkk

Chain 'C':
Sequence, based on SEQRES records: (download)

>6ft9C (C:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkksi

Sequence, based on observed residues (ATOM records): (download)

>6ft9C (C:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkk