PDB entry 6ft8

View 6ft8 on RCSB PDB site
Description: Crystal structure of CLK1 in complex with inhibitor 8g
Class: transferase
Keywords: kinase, inhibitor, splicing kinase, CLK, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Deposited on 2018-02-20, released 2018-05-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-05-16, with a file datestamp of 2018-05-11.
Experiment type: XRAY
Resolution: 1.45 Å
R-factor: N/A
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity protein kinase CLK1
    Species: Homo sapiens [TaxId:9606]
    Gene: CLK1, CLK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49759 (2-End)
      • expression tag (0-1)
      • variant (286)
    Domains in SCOPe 2.08: d6ft8a1, d6ft8a2
  • Heterogens: E6T, NA, EDO, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ft8A (A:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkksi

    Sequence, based on observed residues (ATOM records): (download) 
    >6ft8A (A:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkks