PDB entry 6frx

View 6frx on RCSB PDB site
Description: pka variant as aurora b mimic in complex with a dianilinopyrimidine inhibitor
Deposited on 2018-02-16, released 2019-03-13
The last revision was dated 2019-03-13, with a file datestamp of 2019-03-08.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase catalytic subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: Prkaca, Pkaca
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17612 (Start-350)
      • conflict (47)
      • conflict (95)
      • conflict (120)
      • conflict (123)
      • conflict (181)
      • conflict (183)
  • Chain 'B':
    Compound: cAMP-dependent protein kinase inhibitor alpha
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: E3Z, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6frxA (A:)
mgnaaaakkgseqesvkeflakakedflkkwespaqntahldqferirtlgtgsfgrvml
vkhketgnhyamkildkqkvvklkqiehtlnekriqqavnfpflvklefsfkdnsnlymv
leyapggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgy
ikvadfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppff
adqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfat
tdwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

    Sequence, based on observed residues (ATOM records):
    >6frxA (A:)
qesvkeflakakedflkkwespaqntahldqferirtlgtgsfgrvmlvkhketgnhyam
kildkqkvvklkqiehtlnekriqqavnfpflvklefsfkdnsnlymvleyapggemfsh
lrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyikvadfgfakrv
kgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekiv
sgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkve
apfipkfksnfddyeeeeirvsinekcgkefsef

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >6frxB (B:)
ttyadfiasgrtgrrnaihd