PDB entry 6fp6

View 6fp6 on RCSB PDB site
Description: Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation
Class: metal binding protein
Keywords: heterodimer, copper-chaperone, hSOD1, protein maturation, METAL BINDING PROTEIN
Deposited on 2018-02-09, released 2019-01-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-06-19, with a file datestamp of 2019-06-14.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (0-152)
      • engineered mutation (56)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d6fp6a_
  • Chain 'B':
    Compound: copper chaperone for superoxide dismutase
    Species: Homo sapiens [TaxId:9606]
    Gene: CCS
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14618
      • engineered mutation (11)
      • engineered mutation (21)
      • engineered mutation (24)
  • Chain 'C':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (0-152)
      • engineered mutation (56)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d6fp6c_
  • Chain 'D':
    Compound: copper chaperone for superoxide dismutase
    Species: Homo sapiens [TaxId:9606]
    Gene: CCS
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14618
      • engineered mutation (11)
      • engineered mutation (21)
      • engineered mutation (24)
  • Chain 'E':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (0-152)
      • engineered mutation (56)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d6fp6e_
  • Chain 'F':
    Compound: copper chaperone for superoxide dismutase
    Species: Homo sapiens [TaxId:9606]
    Gene: CCS
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14618
      • engineered mutation (11)
      • engineered mutation (21)
      • engineered mutation (24)
  • Chain 'G':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (0-152)
      • engineered mutation (56)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d6fp6g_
  • Chain 'H':
    Compound: copper chaperone for superoxide dismutase
    Species: Homo sapiens [TaxId:9606]
    Gene: CCS
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14618
      • engineered mutation (11)
      • engineered mutation (21)
      • engineered mutation (24)
  • Chain 'I':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (0-152)
      • engineered mutation (56)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d6fp6i_
  • Chain 'J':
    Compound: copper chaperone for superoxide dismutase
    Species: Homo sapiens [TaxId:9606]
    Gene: CCS
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14618
      • engineered mutation (11)
      • engineered mutation (21)
      • engineered mutation (24)
  • Chain 'K':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (0-152)
      • engineered mutation (56)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d6fp6k_
  • Chain 'L':
    Compound: copper chaperone for superoxide dismutase
    Species: Homo sapiens [TaxId:9606]
    Gene: CCS
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14618
      • engineered mutation (11)
      • engineered mutation (21)
      • engineered mutation (24)
  • Chain 'M':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (0-152)
      • engineered mutation (56)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d6fp6m_
  • Chain 'N':
    Compound: copper chaperone for superoxide dismutase
    Species: Homo sapiens [TaxId:9606]
    Gene: CCS
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14618
      • engineered mutation (11)
      • engineered mutation (21)
      • engineered mutation (24)
  • Chain 'O':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (0-152)
      • engineered mutation (56)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d6fp6o_
  • Chain 'P':
    Compound: copper chaperone for superoxide dismutase
    Species: Homo sapiens [TaxId:9606]
    Gene: CCS
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14618
      • engineered mutation (11)
      • engineered mutation (21)
      • engineered mutation (24)
  • Chain 'Q':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (0-152)
      • engineered mutation (56)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d6fp6q_
  • Chain 'R':
    Compound: copper chaperone for superoxide dismutase
    Species: Homo sapiens [TaxId:9606]
    Gene: CCS
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14618
      • engineered mutation (11)
      • engineered mutation (21)
      • engineered mutation (24)
  • Chain 'S':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (0-152)
      • engineered mutation (56)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d6fp6s_
  • Chain 'T':
    Compound: copper chaperone for superoxide dismutase
    Species: Homo sapiens [TaxId:9606]
    Gene: CCS
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14618
      • engineered mutation (11)
      • engineered mutation (24)
  • Chain 'U':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (0-152)
      • engineered mutation (56)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d6fp6u_
  • Chain 'V':
    Compound: copper chaperone for superoxide dismutase
    Species: Homo sapiens [TaxId:9606]
    Gene: CCS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6fp6v_
  • Chain 'W':
    Compound: Superoxide dismutase [Cu-Zn]
    Species: Homo sapiens [TaxId:9606]
    Gene: SOD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00441 (0-152)
      • engineered mutation (56)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d6fp6w_
  • Chain 'X':
    Compound: copper chaperone for superoxide dismutase
    Species: Homo sapiens [TaxId:9606]
    Gene: CCS
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14618
      • engineered mutation (11)
      • engineered mutation (21)
      • engineered mutation (24)
  • Heterogens: ZN, PPI, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fp6A (A:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagatsa
gphfnplsrkhggpkdeerhvgdlgnvtadkdgvadvsiedsvislsgdhciigrtlvvh
ekaddlgkggneestktgnagsrlaagvigiaq

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fp6C (C:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagatsa
gphfnplsrkhggpkdeerhvgdlgnvtadkdgvadvsiedsvislsgdhciigrtlvvh
ekaddlgkggneestktgnagsrlaagvigiaq

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fp6E (E:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagatsa
gphfnplsrkhggpkdeerhvgdlgnvtadkdgvadvsiedsvislsgdhciigrtlvvh
ekaddlgkggneestktgnagsrlaagvigiaq

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fp6G (G:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagatsa
gphfnplsrkhggpkdeerhvgdlgnvtadkdgvadvsiedsvislsgdhciigrtlvvh
ekaddlgkggneestktgnagsrlaagvigiaq

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fp6I (I:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagatsa
gphfnplsrkhggpkdeerhvgdlgnvtadkdgvadvsiedsvislsgdhciigrtlvvh
ekaddlgkggneestktgnagsrlaagvigiaq

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fp6K (K:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagatsa
gphfnplsrkhggpkdeerhvgdlgnvtadkdgvadvsiedsvislsgdhciigrtlvvh
ekaddlgkggneestktgnagsrlaagvigiaq

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fp6M (M:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagatsa
gphfnplsrkhggpkdeerhvgdlgnvtadkdgvadvsiedsvislsgdhciigrtlvvh
ekaddlgkggneestktgnagsrlaagvigiaq

  • Chain 'N':
    No sequence available.

  • Chain 'O':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fp6O (O:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagatsa
gphfnplsrkhggpkdeerhvgdlgnvtadkdgvadvsiedsvislsgdhciigrtlvvh
ekaddlgkggneestktgnagsrlaagvigiaq

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    Sequence, based on SEQRES records: (download) 
    >6fp6Q (Q:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagatsa
gphfnplsrkhggpkdeerhvgdlgnvtadkdgvadvsiedsvislsgdhciigrtlvvh
ekaddlgkggneestktgnagsrlaagvigiaq

    Sequence, based on observed residues (ATOM records): (download) 
    >6fp6Q (Q:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagatsa
gphfnplsrkhggpkdeerhvgdlgnvtadgvadvsiedsvislsgdhciigrtlvvhek
addlgkggneestktgnagsrlaagvigiaq

  • Chain 'R':
    No sequence available.

  • Chain 'S':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fp6S (S:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagatsa
gphfnplsrkhggpkdeerhvgdlgnvtadkdgvadvsiedsvislsgdhciigrtlvvh
ekaddlgkggneestktgnagsrlaagvigiaq

  • Chain 'T':
    No sequence available.

  • Chain 'U':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fp6U (U:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagatsa
gphfnplsrkhggpkdeerhvgdlgnvtadkdgvadvsiedsvislsgdhciigrtlvvh
ekaddlgkggneestktgnagsrlaagvigiaq

  • Chain 'V':
    Sequence, based on SEQRES records: (download) 
    >6fp6V (V:)
masdsgnqgtlatlefavqmtaqsavdavrkslqgvagvqdvevhledqmvlvhttlpsq
evqallegtgrqavlkgmgsgqlqnlgaavailggpgtvqgvvrflqltpercliegtid
glepglhglhvhqygdltnncnscgnhfnpdgashggpqdsdrhrgdlgnvradadgrai
frmedeqlkvwdvigrsliidegeddlgrgghplskitgnsgerlacgiiarsaglfqnp
kqicscdgltiweergrpiagkgrkesaqppahl

    Sequence, based on observed residues (ATOM records): (download) 
    >6fp6V (V:)
nlgaavailtvqgvvrflqltpercliegtidglepglhglhvhqygdltnncnscgnhf
npdgashggpqdsdrhrgdlgnvradadgraifrmedeqlkvwdvigrsliidegeddlg
rgghplskitgnsgerlacgiiarsa

  • Chain 'W':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fp6W (W:)
atkavcvlkgdgpvqgiinfeqkesngpvkvwgsikglteglhgfhvhefgdntagatsa
gphfnplsrkhggpkdeerhvgdlgnvtadkdgvadvsiedsvislsgdhciigrtlvvh
ekaddlgkggneestktgnagsrlaagvigiaq

  • Chain 'X':
    No sequence available.