PDB entry 6fnk

View 6fnk on RCSB PDB site
Description: Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with a pyrazolo[3,4-d]pyrimidine fragment of NVP-BHG712
Class: transferase
Keywords: Inhibitor, Complex, Protein Tyrosine Kinase, Transferase
Deposited on 2018-02-04, released 2018-08-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-06-12, with a file datestamp of 2019-06-07.
Experiment type: XRAY
Resolution: 1.05 Å
R-factor: N/A
AEROSPACI score: 0.78 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ephrin type-B receptor 4
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHB4, HTK, MYK1, TYRO11
    Database cross-references and differences (RAF-indexed):
    • Uniprot P54760
      • engineered mutation (207)
      • engineered mutation (274)
    Domains in SCOPe 2.08: d6fnka_
  • Heterogens: DXK, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6fnkA (A:)
gmdpneavrefakeidvsyvkieevigagefgevcrgrlkapgkkescvaiktlkggyte
rqrreflseasimgqfehpniirlegvvtnsmpvmiltefmengaldsflrlndgqftvi
qlvgmlrgiasgmrylaemsyvhrdlaarnilvnsnlvckvsdfglsrfleenssdptet
sslggkipirwtapeaiafrkftsasdvwsygivmwevmsfgerpywdmsnqdvinaieq
dyrlppppdcptslhqlmldcwqkdrnarprfpqivsaldkmirnpaslkivareng

    Sequence, based on observed residues (ATOM records): (download) 
    >6fnkA (A:)
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easimgqfehpniirlegvvtnsmpvmiltefmengaldsflrlndgqftviqlvgmlrg
iasgmrylaemsyvhrdlaarnilvnsnlvckvsdfglsrfleegkipirwtapeaiafr
kftsasdvwsygivmwevmsfgerpywdmsnqdvinaieqdyrlppppdcptslhqlmld
cwqkdrnarprfpqivsaldkmirnpaslkivar