SCOPe 2.08: Structural Classification of Proteins

PDB entry 6fmo

View 6fmo on RCSB PDB site
Description: Crystal structure of the substrate (obtusifoliol)-bound and ligand-free I105F mutant of sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi
Class: protein binding
Keywords: sterol biosynthesis, CYP51, OXIDOREDUCTASE, MONOOXYGENASE, SUBSTRATE BINDING, PROTEIN BINDING
Deposited on 2018-02-01, released 2018-10-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-12-26, with a file datestamp of 2018-12-21.
Experiment type: XRAY
Resolution: 3.18 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: sterol 14alpha-demethylase
Species: Trypanosoma cruzi [TaxId:5693]
Gene: CYP51A
Database cross-references and differences (RAF-indexed):
- Uniprot M1FYE4
  - conflict (30)
  - engineered mutation (104)
  - conflict (354)
Domains in SCOPe 2.08: d6fmoa_
Chain 'B':
Compound: sterol 14alpha-demethylase
Species: Trypanosoma cruzi [TaxId:5693]
Gene: CYP51A
Database cross-references and differences (RAF-indexed):
- Uniprot M1FYE4
  - conflict (30)
  - engineered mutation (104)
  - conflict (354)
Domains in SCOPe 2.08: d6fmob_
Chain 'C':
Compound: sterol 14alpha-demethylase
Species: Trypanosoma cruzi [TaxId:5693]
Gene: CYP51A
Database cross-references and differences (RAF-indexed):
- Uniprot M1FYE4
  - conflict (30)
  - engineered mutation (104)
  - conflict (354)
Domains in SCOPe 2.08: d6fmoc_
Chain 'D':
Compound: sterol 14alpha-demethylase
Species: Trypanosoma cruzi [TaxId:5693]
Gene: CYP51A
Database cross-references and differences (RAF-indexed):
- Uniprot M1FYE4
  - conflict (30)
  - engineered mutation (104)
  - conflict (354)
Domains in SCOPe 2.08: d6fmod_
Heterogens: HEM, DVE, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>6fmoA (A:)
mfieaivlgltalilysvysvksfnttrptlppvypvtvpflghivqfgknplefmqrck
rdlksgvftisiggqrvtivgdphehsrffsprneilsprevytfmtpvfgegvayaapy
prmreqlnflaeeltiakfqnfvpaiqhevrkfmaenwkedegvinlledcgamiintac
qclfgedlrkrlnarhfaqllskmesslipaavfmpwllrlplpqsarcrearaelqkil
geiivarekeeaskdnntsdllggllkavyrdgtrmslhevcgmivaamfagqhtstitt
swsmlhlmhpknkkwldklhkeidefpaqlnydnvmdempfaercvresirrdppllmvm
rmvkaevkvgsyvvpkgdiiacspllshhdeeafpnprlwdperdekvdgafigfgagvh
kcigqkfallqvktilatafreydfqllrdevpdpdyhtmvvgptlnqclvkytrkkklp
shhhh

Sequence, based on observed residues (ATOM records): (download)

>6fmoA (A:)
lppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsrff
sprneilsprevytfmtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhev
rkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmesslip
aavfmpwllrlplpqsarcrearaelqkilgeiivarekeeaskdnntsdllggllkavy
rdgtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaql
nydnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhd
eeafpnprlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrd
evpdpdyhtmvvgptlnqclvkytrkkk

Chain 'B':
Sequence, based on SEQRES records: (download)

>6fmoB (B:)
mfieaivlgltalilysvysvksfnttrptlppvypvtvpflghivqfgknplefmqrck
rdlksgvftisiggqrvtivgdphehsrffsprneilsprevytfmtpvfgegvayaapy
prmreqlnflaeeltiakfqnfvpaiqhevrkfmaenwkedegvinlledcgamiintac
qclfgedlrkrlnarhfaqllskmesslipaavfmpwllrlplpqsarcrearaelqkil
geiivarekeeaskdnntsdllggllkavyrdgtrmslhevcgmivaamfagqhtstitt
swsmlhlmhpknkkwldklhkeidefpaqlnydnvmdempfaercvresirrdppllmvm
rmvkaevkvgsyvvpkgdiiacspllshhdeeafpnprlwdperdekvdgafigfgagvh
kcigqkfallqvktilatafreydfqllrdevpdpdyhtmvvgptlnqclvkytrkkklp
shhhh

Sequence, based on observed residues (ATOM records): (download)

>6fmoB (B:)
lppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsrff
sprneilsprevytfmtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhev
rkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmesslip
aavfmpwllrlplpqsarcrearaelqkilgeiivarekeeaskdnntsdllggllkavy
rdgtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaql
nydnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhd
eeafpnprlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrd
evpdpdyhtmvvgptlnqclvkytrkkk

Chain 'C':
Sequence, based on SEQRES records: (download)

>6fmoC (C:)
mfieaivlgltalilysvysvksfnttrptlppvypvtvpflghivqfgknplefmqrck
rdlksgvftisiggqrvtivgdphehsrffsprneilsprevytfmtpvfgegvayaapy
prmreqlnflaeeltiakfqnfvpaiqhevrkfmaenwkedegvinlledcgamiintac
qclfgedlrkrlnarhfaqllskmesslipaavfmpwllrlplpqsarcrearaelqkil
geiivarekeeaskdnntsdllggllkavyrdgtrmslhevcgmivaamfagqhtstitt
swsmlhlmhpknkkwldklhkeidefpaqlnydnvmdempfaercvresirrdppllmvm
rmvkaevkvgsyvvpkgdiiacspllshhdeeafpnprlwdperdekvdgafigfgagvh
kcigqkfallqvktilatafreydfqllrdevpdpdyhtmvvgptlnqclvkytrkkklp
shhhh

Sequence, based on observed residues (ATOM records): (download)

>6fmoC (C:)
lppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsrff
sprneilsprevytfmtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhev
rkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmesslip
aavfmpwllrlplpqsarcrearaelqkilgeiivarekeeaskdnntsdllggllkavy
rdgtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaql
nydnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhd
eeafpnprlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrd
evpdpdyhtmvvgptlnqclvkytrkkk

Chain 'D':
Sequence, based on SEQRES records: (download)

>6fmoD (D:)
mfieaivlgltalilysvysvksfnttrptlppvypvtvpflghivqfgknplefmqrck
rdlksgvftisiggqrvtivgdphehsrffsprneilsprevytfmtpvfgegvayaapy
prmreqlnflaeeltiakfqnfvpaiqhevrkfmaenwkedegvinlledcgamiintac
qclfgedlrkrlnarhfaqllskmesslipaavfmpwllrlplpqsarcrearaelqkil
geiivarekeeaskdnntsdllggllkavyrdgtrmslhevcgmivaamfagqhtstitt
swsmlhlmhpknkkwldklhkeidefpaqlnydnvmdempfaercvresirrdppllmvm
rmvkaevkvgsyvvpkgdiiacspllshhdeeafpnprlwdperdekvdgafigfgagvh
kcigqkfallqvktilatafreydfqllrdevpdpdyhtmvvgptlnqclvkytrkkklp
shhhh

Sequence, based on observed residues (ATOM records): (download)

>6fmoD (D:)
lppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsrff
sprneilsprevytfmtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhev
rkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmesslip
aavfmpwllrlplpqsarcrearaelqkilgeiivarekeeaskdnntsdllggllkavy
rdgtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaql
nydnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhd
eeafpnprlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrd
evpdpdyhtmvvgptlnqclvkytrkkk