PDB entry 6fl5

View 6fl5 on RCSB PDB site
Description: structure of human shmt1-h135n-r137a-e168n mutant at 3.6 ang. resolution
Deposited on 2018-01-25, released 2018-10-10
The last revision was dated 2018-10-10, with a file datestamp of 2018-10-05.
Experiment type: XRAY
Resolution: 3.6 Å
R-factor: N/A
AEROSPACI score: 0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine hydroxymethyltransferase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: SHMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P34896 (0-470)
      • engineered mutation (124)
      • engineered mutation (126)
      • engineered mutation (157)
  • Chain 'D':
    Compound: Serine hydroxymethyltransferase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: SHMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P34896 (0-End)
      • engineered mutation (124)
      • engineered mutation (126)
      • engineered mutation (157)
  • Chain 'G':
    Compound: Serine hydroxymethyltransferase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: SHMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P34896 (0-End)
      • engineered mutation (124)
      • engineered mutation (126)
      • engineered mutation (157)
  • Chain 'J':
    Compound: Serine hydroxymethyltransferase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: SHMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P34896
      • engineered mutation (124)
      • engineered mutation (126)
      • engineered mutation (157)
  • Heterogens: PLP, CL

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records:
    >6fl5A (A:)
dadlwsshdkmlaqplkdsdvevyniikkesnrqrvgleliasenfasravlealgscln
nkysegypgqryyggtefideletlcqkralqaykldpqcwgvnvqpysgspanfavyta
lvepngaimgldlpdgghlthgfmtdkkkisatsiffnsmpykvnpdtgyinydqleena
rlfhpkliiagtscysrnleyarlrkiadengaylmadmahisglvaagvvpspfehchv
vtttthktlrgcragmifyrkgvksvdpktgkeilynleslinsavfpglqggphnhaia
gvavalkqamtlefkvyqhqvvancralsealtelgykivtggsdnhlilvdlrskgtdg
graekvleacsiacnkntcpgdrsalrpsglrlgtpaltsrgllekdfqkvahfihrgie
ltlqiqsdtgvratlkefkerlagdkyqaavqalreevesfaslfplpglp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6fl5D (D:)
dadlwsshdkmlaqplkdsdvevyniikkesnrqrvgleliasenfasravlealgscln
nkysegypgqryyggtefideletlcqkralqaykldpqcwgvnvqpysgspanfavyta
lvepngaimgldlpdgghlthgfmtdkkkisatsiffnsmpykvnpdtgyinydqleena
rlfhpkliiagtscysrnleyarlrkiadengaylmadmahisglvaagvvpspfehchv
vtttthktlrgcragmifyrkgvksvdpktgkeilynleslinsavfpglqggphnhaia
gvavalkqamtlefkvyqhqvvancralsealtelgykivtggsdnhlilvdlrskgtdg
graekvleacsiacnkntcpgdrsalrpsglrlgtpaltsrgllekdfqkvahfihrgie
ltlqiqsdtgvratlkefkerlagdkyqaavqalreevesfaslfplpglp

    Sequence, based on observed residues (ATOM records):
    >6fl5D (D:)
dadlwsshdkmlaqplkdsdvevyniikkesnrqrvgleliasenfasravlealgscln
nkysegypgqryyggtefideletlcqkralqaykldpqcwgvnvqpysgspanfavyta
lvepngaimgldlpdgghlthgfmtdkkkisatsiffnsmpykvnpdtgyinydqleena
rlfhpkliiagtscysrnleyarlrkiadengaylmadmahisglvaagvvpspfehchv
vtttthktlrgcragmifyrkgvksvdpktgkeilynleslinsavfpglqggphnhaia
gvavalkqamtlefkvyqhqvvancralsealtelgykivtggsdnhlilvdlrskgtdg
graekvleacsiacnkntcpgdrsalrpsglrlgtpaltsrgllekdfqkvahfihrgie
ltlqiqsdtgvratlkefkerlagdkyqaavqalreevesfaslfplpgl

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6fl5G (G:)
dadlwsshdkmlaqplkdsdvevyniikkesnrqrvgleliasenfasravlealgscln
nkysegypgqryyggtefideletlcqkralqaykldpqcwgvnvqpysgspanfavyta
lvepngaimgldlpdgghlthgfmtdkkkisatsiffnsmpykvnpdtgyinydqleena
rlfhpkliiagtscysrnleyarlrkiadengaylmadmahisglvaagvvpspfehchv
vtttthktlrgcragmifyrkgvksvdpktgkeilynleslinsavfpglqggphnhaia
gvavalkqamtlefkvyqhqvvancralsealtelgykivtggsdnhlilvdlrskgtdg
graekvleacsiacnkntcpgdrsalrpsglrlgtpaltsrgllekdfqkvahfihrgie
ltlqiqsdtgvratlkefkerlagdkyqaavqalreevesfaslfplpglp

    Sequence, based on observed residues (ATOM records):
    >6fl5G (G:)
dadlwsshdkmlaqplkdsdvevyniikkesnrqrvgleliasenfasravlealgscln
nkysegypgqryyggtefideletlcqkralqaykldpqcwgvnvqpysgspanfavyta
lvepngaimgldlpdgghlthgfmtdkkkisatsiffnsmpykvnpdtgyinydqleena
rlfhpkliiagtscysrnleyarlrkiadengaylmadmahisglvaagvvpspfehchv
vtttthktlrgcragmifyrkgvksvdpktgkeilynleslinsavfpglqggphnhaia
gvavalkqamtlefkvyqhqvvancralsealtelgykivtggsdnhlilvdlrskgtdg
graekvleacsiacnkntcpgdrsalrpsglrlgtpaltsrgllekdfqkvahfihrgie
ltlqiqsdtatlkefkerlagdkyqaavqalreevesfaslfplpgl

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6fl5J (J:)
dadlwsshdkmlaqplkdsdvevyniikkesnrqrvgleliasenfasravlealgscln
nkysegypgqryyggtefideletlcqkralqaykldpqcwgvnvqpysgspanfavyta
lvepngaimgldlpdgghlthgfmtdkkkisatsiffnsmpykvnpdtgyinydqleena
rlfhpkliiagtscysrnleyarlrkiadengaylmadmahisglvaagvvpspfehchv
vtttthktlrgcragmifyrkgvksvdpktgkeilynleslinsavfpglqggphnhaia
gvavalkqamtlefkvyqhqvvancralsealtelgykivtggsdnhlilvdlrskgtdg
graekvleacsiacnkntcpgdrsalrpsglrlgtpaltsrgllekdfqkvahfihrgie
ltlqiqsdtgvratlkefkerlagdkyqaavqalreevesfaslfplpglp

    Sequence, based on observed residues (ATOM records):
    >6fl5J (J:)
sshdkmlaqplkdsdvevyniikkesnrqrvgleliasenfasravlealgsclnnkyse
gypgqryyggtefideletlcqkralqaykldpqcwgvnvqpysgspanfavytalvepn
gaimgldlpdgghlthgfmtdkkkisatsiffnsmpykvnpdtgyinydqleenarlfhp
kliiagtscysrnleyarlrkiadengaylmadmahisglvaagvvpspfehchvvtttt
hktlrgcragmifyrkgvksvdpktgkeilynleslinsavfpglqggphnhaiagvava
lkqamtlefkvyqhqvvancralsealtelgykivtggsdnhlilvdlrskgtdggraek
vleacsiacnkntcpgdrsalrpsglrlgtpaltsrgllekdfqkvahfihrgieltlqi
qslkefkerlagdkyqaavqalreevesfaslfplpgl